苄氧羰基-甘氨酰-脯氨酰-琥珀酰亚胺合成路线 （共 4 条）
反应条件
dicyclohexyl-carbodiimide in ethylene glycol dimethyl ether
T=0°C; 12 h;
参考文献
Baldwin, Jack E.; Brown, David; Scudder, Paul H.; Wood, Mark E.
Tetrahedron Letters, 1995 , vol. 36, # 12 p. 2105 - 2108
反应条件
1: 0.88 g / 1,3-dicyclohexylcarbodiimide; triethylamine / CH2Cl2 / 18 h / 20 °C
2: NaOH / H2O; dioxane / 21 h / 20 °C
3: 69 percent / 1,3-dicyclohexylcarbodiimide / 1,2-dimethoxy-ethane / 17 h / 20 °C
View Scheme
参考文献
Trotter, Nicholas S.; Brimble, Margaret A.; Harris, Paul W.R.; Callis, David J.; Sieg, Frank
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 2 p. 501 - 517
反应条件
1: NaOH / H2O; dioxane / 21 h / 20 °C
2: 69 percent / 1,3-dicyclohexylcarbodiimide / 1,2-dimethoxy-ethane / 17 h / 20 °C
View Scheme
参考文献
Trotter, Nicholas S.; Brimble, Margaret A.; Harris, Paul W.R.; Callis, David J.; Sieg, Frank
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 2 p. 501 - 517
反应条件
1: 98 percent / SOCl2 / 19 h / 20 °C
2: 0.88 g / 1,3-dicyclohexylcarbodiimide; triethylamine / CH2Cl2 / 18 h / 20 °C
3: NaOH / H2O; dioxane / 21 h / 20 °C
4: 69 percent / 1,3-dicyclohexylcarbodiimide / 1,2-dimethoxy-ethane / 17 h / 20 °C
View Scheme
参考文献
Trotter, Nicholas S.; Brimble, Margaret A.; Harris, Paul W.R.; Callis, David J.; Sieg, Frank
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 2 p. 501 - 517
