2-(Boc-氨基)吡啶合成路线 （共 33 条）
反应条件
tert.-butyl lithium in tetrahydrofuran; pentane 1.) -78 deg C, 15 min, -20 deg C, 1.5 h, 2.) -15 deg C to room temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 11 p. 2136 - 2145
反应条件
in diethyl ether; ethyl acetate
参考文献
US6479512 B1, ;
US 6479512 B1
反应条件
1: pyridin-2-yl-carbamic acid tert-butyl ester With N,N,N',N,-tetramethylethylenediamine; sec.-butyllithium in tetrahydrofuran; hexane T=-78°C; 2: 1-chloro-3-iodo-propane in tetrahydrofuran Heating; Further stages.;
参考文献
Davies, Antony J.; Brands, Karel M. J.; Cowden, Cameron J.; Dolling, Ulf-H.; Lieberman, David R.
Tetrahedron Letters, 2004 , vol. 45, # 8 p. 1721 - 1724
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 - 5 °C 1.2: 1.5 h / 20 °C 2.1: copper dichloride; isopentyl nitrite / acetonitrile / 0.08 h / 65 °C View Scheme
参考文献
Sucunza, David; Samadi, Abdelouahid; Chioua, Mourad; Silva, Daniel B.; Yunta, Cristina; Infantes, Lourdes; Carmo Carreiras; Soriano, Elena; Marco-Contelles, Jose
Chemical Communications, 2011 , vol. 47, # 17 p. 5043 - 5045
参考文献
Medivir AB
Patent: US5593993 A1, 1997 ;
参考文献
Medivir AB
Patent: US5593993 A1, 1997 ;
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 5 °C 1.2: 1.5 h / 5 - 20 °C 2.1: trifluoroacetic acid / water; dichloromethane View Scheme
参考文献
Liang, Dongdong; He, Yimiao; Liu, Lanying; Zhu, Qiang
Organic Letters, 2013 , vol. 15, # 13 p. 3476 - 3479
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 5 °C 1.2: 1.5 h / 5 - 20 °C 2.1: trifluoroacetic acid / water; dichloromethane View Scheme
参考文献
Liang, Dongdong; He, Yimiao; Liu, Lanying; Zhu, Qiang
Organic Letters, 2013 , vol. 15, # 13 p. 3476 - 3479
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 5 °C
1.2: 1.5 h / 5 - 20 °C
2.1: trifluoroacetic acid / water; dichloromethane
3.1: PhI(OPiv)2 / 7 h / 25 °C
View Scheme
参考文献
Liang, Dongdong; He, Yimiao; Liu, Lanying; Zhu, Qiang
Organic Letters, 2013 , vol. 15, # 13 p. 3476 - 3479
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 5 °C
1.2: 1.5 h / 5 - 20 °C
2.1: trifluoroacetic acid / water; dichloromethane
View Scheme
参考文献
Liang, Dongdong; He, Yimiao; Liu, Lanying; Zhu, Qiang
Organic Letters, 2013 , vol. 15, # 13 p. 3476 - 3479
