1-三甲基硅烷-1-己炔合成路线 （共 85 条）
反应条件
1: 1-iodo-butane With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triphenylphosphine in tetrahydrofuran T=25°C; Sonogashira coupling; 0.166667 h; Inert atmosphere; 2: trimethylsilylacetylene With triethylamine in tetrahydrofuran T=25°C; Sonogashira coupling; 12 h; Inert atmosphere;
参考文献
Teiber, Marco; Mueller, Thomas J. J.
Chemical Communications, 2012 , vol. 48, # 15 p. 2080 - 2082
反应条件
(Me2SiCp''2UBu)2O*2THF in tetrahydrofuran T=66°C; 23 h; Product distribution; Further Variations:reaction time;
参考文献
Wang, Jiaxi; Gurevich, Ylia; Botoshansky, Mark; Eisen, Moris S.
Journal of the American Chemical Society, 2006 , vol. 128, # 29 p. 9350 - 9351
反应条件
samarium diiodide in tetrahydrofuran 24 h; Heating;
参考文献
Zhou, Zhihong; Larouche, Denis; Bennett, Sharon M.
Tetrahedron, 1995 , vol. 51, # 43 p. 11623 - 11644
反应条件
N,N'-dimethyl-N,N'-propyleneurea; samarium diiodide in tetrahydrofuran 24 h; Ambient temperature;
参考文献
Zhou, Zhihong; Larouche, Denis; Bennett, Sharon M.
Tetrahedron, 1995 , vol. 51, # 43 p. 11623 - 11644
反应条件
n-butyllithium 1) hexane, THF, -10 deg C, 30 min, 2) HMPT, a) -30 deg C, 2 h, b) r.t., 3 h; Yield given. Multistep reaction;
参考文献
Poleschner; Heydenreich; Martin
Synthesis, 1991 , # 12 p. 1231 - 1235
反应条件
lithium amide 1) NH3(l), THF, -33 deg C, 30 min, 2) -33 deg C, 6 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Poleschner; Heydenreich; Martin
Synthesis, 1991 , # 12 p. 1231 - 1235
反应条件
(i) nBuLi, Me2NCH2CH2NMe2, (ii) /BRN= 1071220/, (iii) AcOH, HMPT; Multistep reaction;
参考文献
Yogo,T. et al.
Synthetic Communications, 1979 , vol. 9, p. 809 - 817
反应条件
bis(cyclopentadienyl)titanium dichloride; 2-methylpropylmagnesium bromide Yield given. Multistep reaction;
参考文献
Sato, Fumie; Tanaka, Youichi; Sato, Masao
Journal of the Chemical Society, Chemical Communications, 1983 , # 4 p. 165 - 166
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 1.5 h / 20 °C 1.2: MgBr2 / tetrahydrofuran; hexane / 0.5 h / 20 °C 1.3: tetrahydrofuran; hexane / 3 h / 20 °C 2.1: NaOH / methanol; tetrahydrofuran; H2O 3.1: LiHMDS / tetrahydrofuran / -78 °C 3.2: lithium tert-butyl peroxide / tetrahydrofuran; toluene / 2.5 h / -78 - 0 °C 3.3: 80 percent / tetrahydrofuran; toluene / 0.5 h / 0 °C 4.1: 74 percent / HNTf2 / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Zhang, Liming; Kozmin, Sergey A.
Journal of the American Chemical Society, 2004 , vol. 126, # 33 p. 10204 - 10205
反应条件
in dichloromethane N2-atmosphere; dropwise addn. of 1.2-1.6 equiv. of silane to BCl3, stirring (25°C, 3.5 h); not isolated, detd. by NMR spectroscopy;
参考文献
Singleton, Daniel A.; Leung, Shun-Wang
Journal of Organometallic Chemistry, 1997 , vol. 544, # 2 p. 157 - 161
