1-三甲基硅烷-1-己炔合成路线 （共 85 条）
反应条件
1,3-dimethyl-imidazolidin-2-one; copper(l) chloride
T=80°C; 2 h;
参考文献
Montel, Florian; Beaudegnies, Renaud; Kessabi, Jilali; Martin, Benjamin; Muller, Eric; Wendeborn, Sebastian; Jung, Pierre M. J.
Organic Letters, 2006 , vol. 8, # 9 p. 1905 - 1908
反应条件
copper(II) sulfate
T=140 - 145°C; 10 h; Further byproducts given. Title compound not separated from byproducts;
参考文献
Dolgii, I. E.; Okonnishnikova, G. P.; Ignatenko, A. V.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1986 , vol. 35, # 4 p. 864 - 867
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1986 , # 4 p. 947 - 950
反应条件
copper(II) sulfate
T=140 - 145°C; 10 h; Further byproducts given. Title compound not separated from byproducts;
参考文献
Dolgii, I. E.; Okonnishnikova, G. P.; Ignatenko, A. V.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1986 , vol. 35, # 4 p. 864 - 867
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1986 , # 4 p. 947 - 950
参考文献
Uchida,K. et al.
Tetrahedron, 1977 , vol. 33, p. 2987 - 2992
反应条件
1: 1) DIBAH, 2) I2 / 1) Et2O, hexane, a) r.t., 0.5 h, b) 40 deg C, 1 h, 2) Et2O, -78 deg C, 1 h
2: NaOMe / methanol / 4 h / 40 °C
View Scheme
参考文献
Neumann,H.; Seebach,D.
Chemische Berichte, 1978 , vol. 111, p. 2785 - 2812
反应条件
1.1: Cp2Zr(H)Cl / tetrahydrofuran / 20 °C
1.2: 60 percent / CuBr*Me2S / tetrahydrofuran / 4 h / 25 °C
2.1: MCPBA / CH2Cl2 / 20 °C
3.1: TFA / methanol / 2 h / Heating
View Scheme
参考文献
Zheng, Weixin; Huang, Xian
Synthesis, 2002 , # 17 p. 2497 - 2502
反应条件
1: in benzene
T=80°C; 16 h; Inert atmosphere;
2: With ammonium cerium (IV) nitrate in diethyl ether; benzene
T=20°C; 3 h; Inert atmosphere;
参考文献
Wu, Chunrui; Berbasov, Dmytro O.; Wulff, William D.
Journal of Organic Chemistry, 2010 , vol. 75, # 13 p. 4441 - 4452
反应条件
silver tetrafluoroborate; Co(PPh3)2Cl
2.) CH3CN, 110 deg C, 20 - 40 h; Yield given. Multistep reaction;
参考文献
Liebeskind, Lenny S.; Baysdon, Sherol L.; South, Michael S.; Iyer, Suresh; Leeds, James P.
Tetrahedron, 1985 , vol. 41, # 24 p. 5839 - 5853
反应条件
1.1: n-BuLi / tetrahydrofuran; petroleum ether / 1.5 h / 20 °C
1.2: MgBr2 / tetrahydrofuran; petroleum ether / 0.5 h / 20 °C
1.3: tetrahydrofuran; petroleum ether / 20 °C
2.1: aq. NaOH / methanol; tetrahydrofuran
3.1: LiHMDS; t-BuOOLi / tetrahydrofuran; toluene / 2.5 h / -78 - 0 °C
3.2: 80 percent / tetrahydrofuran; toluene / -78 - 0 °C
View Scheme
参考文献
Zhang, Liming; Kozmin, Sergey A.
Journal of the American Chemical Society, 2004 , vol. 126, # 33 p. 10204 - 10205
反应条件
1.1: n-BuLi / tetrahydrofuran; petroleum ether / 1.5 h / 20 °C
1.2: MgBr2 / tetrahydrofuran; petroleum ether / 0.5 h / 20 °C
1.3: tetrahydrofuran; petroleum ether / 20 °C
2.1: aq. NaOH / methanol; tetrahydrofuran
3.1: LiHMDS; t-BuOOLi / tetrahydrofuran; toluene / 2.5 h / -78 - 0 °C
3.2: 98 percent / tetrahydrofuran; toluene / -78 - 0 °C
View Scheme
参考文献
Zhang, Liming; Kozmin, Sergey A.
Journal of the American Chemical Society, 2004 , vol. 126, # 33 p. 10204 - 10205
