1-三甲基硅烷-1-己炔合成路线 （共 85 条）
反应条件
2: Br2 / CH2Cl2; CCl4
3: Na / methanol / 24 h / Ambient temperature
4: (i) tBuLi, ether, THF, pentane, (ii) /BRN= 1730824/, THF
View Scheme
参考文献
Neumann,H.; Seebach,D.
Chemische Berichte, 1978 , vol. 111, p. 2785 - 2812
反应条件
1: With AlCl3, aluminium chloride in tetrachloromethane
T=2 - 20°C; 25 h;
2: With hydrogenchloride; water in tetrachloromethane
T=0°C; 1 h;
参考文献
ROTTAPHARM S.p.A.
Patent: WO2005/105789 A2, 2005 ;
Location in patent: Page/Page column 8-9 ;
WO 2005/105789 A2
反应条件
trimethylamine-N-oxide; dimethylsulfide borane complex; water
1.) THF, 0-5 deg C, 2 h; 2.) reflux, 4 h; 3.) 5 min;
参考文献
Miller, Joseph A.; Zweifel, George
Synthesis, 1981 , # 4 p. 288 - 289
反应条件
1: methanol; potassium hydroxide / water / 12 h / 0 - 25 °C / Darkness; Inert atmosphere
2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 2 h / 25 °C / Inert atmosphere
View Scheme
参考文献
Teiber, Marco; Mueller, Thomas J. J.
Chemical Communications, 2012 , vol. 48, # 15 p. 2080 - 2082
反应条件
n-butyllithium; N,N,N',N,-tetramethylethylenediamine
1.) ether, hexane, -20 deg C, 2 h, 10 deg C, 1 h, 2.) -20 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Lockhart, Thomas P.; Comita, Paul B.; Bergman, Robert G.
Journal of the American Chemical Society, 1981 , vol. 103, # 14 p. 4082 - 4090
