1-(4-羟基苯基)-2-苯基乙烷-1,2-二酮合成路线 （共 12 条）
反应条件
dimethyl sulfoxide; palladium dichloride
T=140°C; 2 h;
参考文献
Mousset, Celine; Provot, Olivier; Hamze, Abdallah; Bignon, Jerome; Brion, Jean-Daniel; Alami, Mouad
Tetrahedron, 2008 , vol. 64, # 19 p. 4287 - 4294
反应条件
sodium; diphenyldisulfane in 1-methyl-pyrrolidin-2-one
0.25 h; Heating;
参考文献
Chakraborti, Asit K.; Nayak, Mrinal K.; Sharma, Lalima
Journal of Organic Chemistry, 2002 , vol. 67, # 6 p. 1776 - 1780
反应条件
hydrogenchloride in ethylene glycol dimethyl ether; water; ethyl acetate
参考文献
3M Innovative Properties Company
Patent: US6245922 B1, 2001 ;
反应条件
selenium(IV) oxide in 1,4-dioxane; water
33 h; Heating;
参考文献
Scheithauer
Pharmazie, 1988 , vol. 43, # 2 p. 86 - 90
反应条件
formaldehyd; trifluoroacetic acid in chloroform
72 h; Ambient temperature;
参考文献
Yamamori, Teruo; Adachi, Ikuo
Tetrahedron Letters, 1980 , vol. 21, p. 1747 - 1750
反应条件
1: 1.) n-BuLi / 1.) TMEDA, -78 deg C, 2.) THF, -78 deg C, overnight
2: 86.4 percent / CF3COOH, 35 percent aq. CH2O / CHCl3 / 72 h / Ambient temperature
View Scheme
参考文献
Yamamori, Teruo; Adachi, Ikuo
Tetrahedron Letters, 1980 , vol. 21, p. 1747 - 1750
反应条件
1: n-BuLi / tetrahydrofuran
2: 1.) n-BuLi / 1.) TMEDA, -78 deg C, 2.) THF, -78 deg C, overnight
3: 86.4 percent / CF3COOH, 35 percent aq. CH2O / CHCl3 / 72 h / Ambient temperature
View Scheme
参考文献
Yamamori, Teruo; Adachi, Ikuo
Tetrahedron Letters, 1980 , vol. 21, p. 1747 - 1750
反应条件
1: 60 percent / AlCl3 / nitrobenzene / 5 h / 50 °C
2: 95 percent / SeO2 / dioxane; H2O / 33 h / Heating
View Scheme
参考文献
Scheithauer
Pharmazie, 1988 , vol. 43, # 2 p. 86 - 90
反应条件
1: 60 percent / AlCl3 / nitrobenzene / 5 h / 50 °C
2: 95 percent / SeO2 / dioxane; H2O / 33 h / Heating
View Scheme
参考文献
Scheithauer
Pharmazie, 1988 , vol. 43, # 2 p. 86 - 90
反应条件
1: boron trifluoride diethyl etherate / 20 h / 75 °C / |Reflux; |Inert atmosphere
2: selenium(IV) oxide / 1,4-dioxane; water / 24 h / |Reflux
View Scheme
参考文献
Zarghi; Arfaei; Shirazi
Medicinal Chemistry Research, 2013 , vol. 22, # 8 p. 3897 - 3904
