6-氟-2,3-二氢喹啉-4-酮合成路线 (共 5 条)
反应条件
trifluorormethanesulfonic acid in 1,2-dichloro-ethane
T=0 - 20°C; 0.25 h;
参考文献
Anderson, Kevin W.; Tepe, Jetze J.
Organic Letters, 2002 , vol. 4, # 3 p. 459 - 461
反应条件
trifluorormethanesulfonic acid
T=0 - 20°C; 0.25 h;
参考文献
Anderson, Kevin W.; Tepe, Jetze J.
Tetrahedron, 2002 , vol. 58, # 42 p. 8475 - 8481
反应条件
1: potassium carbonate / dichloromethane / 3 h / 20 °C
2: sodium t-butanolate / N,N-dimethyl-formamide / 2 h / 20 °C
3: trifluorormethanesulfonic acid / 1,2-dichloro-ethane
View Scheme
参考文献
Schmidt, Robert G.; Bayburt, Erol K.; Latshaw, Steven P.; Koenig, John R.; Daanen, Jerome F.; McDonald, Heath A.; Bianchi, Bruce R.; Zhong, Chengmin; Joshi, Shailen; Honore, Prisca; Marsh, Kennan C.; Lee, Chih-Hung; Faltynek, Connie R.; Gomtsyan, Arthur
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 5 p. 1338 - 1341
反应条件
1: copper(l) iodide; potassium carbonate / toluene / 20 h / 18 - 140 °C / Inert atmosphere; Sealed
2: trifluorormethanesulfonic acid / dichloromethane / 1 h / 0 - 18 °C / Inert atmosphere
View Scheme
参考文献
Lange, Jens; Bissember, Alex C.; Banwell, Martin G.; Cade, Ian A.
Australian Journal of Chemistry, 2011 , vol. 64, # 4 p. 454 - 470
反应条件
1: potassium hydroxide; 18-crown-6 ether / dichloromethane / 20 °C
2: trifluorormethanesulfonic acid / dichloromethane / 1.75 h / 0 - 20 °C
View Scheme
参考文献
BAYER PHARMA AKTIENGESELLSCHAFT; VAKALOPOULOS, Alexandros; FOLLMANN, Markus; HARTUNG, Ingo; BUCHGRABER, Philipp; JAUTELAT, Rolf; HAßFELD, Jorma; LINDNER, Niels; WUNDER, Frank; STASCH, Johannes-Peter; REDLICH, Gorden; LI, Volkhart Min-Jian; BECKER, Eva-Maria; KNORR, Andreas
Patent: US2014/128372 A1, 2014 ;