2-氨基-3,3-二甲基丁酸甲酯合成路线 （共 7 条）
反应条件
(i) liq. NH3, (ii) (racemate resolution using D-tartaric acid), (iii) aq. HCl; Multistep reaction;
参考文献
Tanabe,T. et al.
Bulletin of the Chemical Society of Japan, 1968 , vol. 41, p. 2178 - 2179
参考文献
Izumiya et al.
Journal of Biological Chemistry, 1953 , vol. 205, p. 221,229
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Croft, Anna K.; Easton, Christopher J.; Radom, Leo
Journal of the American Chemical Society, 2003 , vol. 125, # 14 p. 4119 - 4124
反应条件
sodium cyanoborohydride in methanol
0.25 h; Ambient temperature;
参考文献
Matsuda, Yoshihiko; Tanimoto, Shigeo; Okamoto, Tadashi; Ali, Syed Mashhood
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 279 - 281
反应条件
1: 80 percent / butyl-lithium, chlorotrimethylsilane / hexane; tetrahydrofuran / 1 h / 0 °C
2: 90 percent Chromat. / NaBH3CN / methanol / 0.25 h / Ambient temperature
View Scheme
参考文献
Matsuda, Yoshihiko; Tanimoto, Shigeo; Okamoto, Tadashi; Ali, Syed Mashhood
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 279 - 281
反应条件
hydrogenchloride in tetrahydrofuran; water
48 h; Yield given;
参考文献
Schoellkopf, Ulrich; Busse, Ulrich; Lonsky, Ralph; Hinrichs, Rolf
Liebigs Annalen der Chemie, 1986 , # 12 p. 2150 - 2163
反应条件
hydrogenchloride in tetrahydrofuran; water
48 h; Yield given. Yields of byproduct given;
参考文献
Schoellkopf, Ulrich; Busse, Ulrich; Lonsky, Ralph; Hinrichs, Rolf
Liebigs Annalen der Chemie, 1986 , # 12 p. 2150 - 2163
反应条件
(i) Et2O, (ii) Al-Hg, H2O; Multistep reaction;
参考文献
Pracejus,H.; Winter,S.
Chemische Berichte, 1964 , vol. 97, p. 3173 - 3182
