1-(苯基甲基)-2,3,4,9-四氢-1H-吡啶并[3,4-b]吲哚合成路线 （共 15 条）
反应条件
sodium tetrahydroborate
T=20°C; 12 h;
参考文献
Espinoza-Moraga, Marlene; Caballero, Julio; Gaube, Friedemann; Winckler, Thomas; Santos, Leonardo S.
Chemical Biology and Drug Design, 2012 , vol. 79, # 4 p. 594 - 599
参考文献
Hahn; Ludewig
Chemische Berichte, 1934 , vol. 67, p. 2031,2034
反应条件
trifluoroacetic acid in acetonitrile
3 h; Heating;
参考文献
Hiemstra, H. C.; Bieraeugel, H.; Wijnberg, M.; Pandit, U. K.
Tetrahedron, 1983 , vol. 39, # 23 p. 3981 - 3986
反应条件
hydrogenchloride in acetonitrile
0.2 h; Ambient temperature;
参考文献
Singh, Harjit; Sarin, Rakesh
Journal of Chemical Research, Miniprint, 1988 , # 10 p. 2623 - 2640
反应条件
acetic acid in acetonitrile
10 h; Ambient temperature;
参考文献
Singh
Indian Journal of Chemistry - Section B Organic Chemistry Including Medicinal Chemistry, 1989 , vol. 28, # 10 p. 802 - 805
反应条件
1: Ac2O, AcONa / 4 h / 100 °C
2: 1.) 1.0 N aq. NaOH, 2.) aq. HCl / 1.) steam bath, 2.) reflux, 4 h
3: ethanol / Heating
View Scheme
参考文献
Audia, James E.; Evrard, Deborah A.; Murdoch, Gwyn R.; Droste, James J.; Nissen, Jeffrey S.; Schenck, Kathy W.; Fludzinski, Pawel; Lucaites, Virginia L.; Nelson, David L.; Cohen, Marlene L.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 14 p. 2773 - 2780
反应条件
1: 1.) 1.0 N aq. NaOH, 2.) aq. HCl / 1.) steam bath, 2.) reflux, 4 h
2: ethanol / Heating
View Scheme
参考文献
Audia, James E.; Evrard, Deborah A.; Murdoch, Gwyn R.; Droste, James J.; Nissen, Jeffrey S.; Schenck, Kathy W.; Fludzinski, Pawel; Lucaites, Virginia L.; Nelson, David L.; Cohen, Marlene L.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 14 p. 2773 - 2780
参考文献
Nakagawa, Masako; Kawate, Tomohiko; Yamazaki, Hitoshi; Hino, Thoru
Journal of the Chemical Society, Chemical Communications, 1990 , # 14 p. 991 - 992
反应条件
1: 63 percent / tetrahydrofuran / -78 deg C, then RT
2: 80 percent / trifluoroacetic acid / acetonitrile / 3 h / Heating
View Scheme
参考文献
Hiemstra, H. C.; Bieraeugel, H.; Wijnberg, M.; Pandit, U. K.
Tetrahedron, 1983 , vol. 39, # 23 p. 3981 - 3986
反应条件
2: POCl3; benzene
3: sodium; ethanol
View Scheme
参考文献
Hahn; Ludewig
Chemische Berichte, 1934 , vol. 67, p. 2031,2034
