5-甲基-2-硝基苯甲醚合成路线 （共 55 条）
反应条件
1.1: SnCl2·2H2O / methanol / 3 h / Reflux 1.2: pH 8 2.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 0.33 h / 65 °C / Inert atmosphere View Scheme
参考文献
KATHOLIEKE UNIVERSITEIT LEUVEN
Patent: US2012/316161 A1, 2012 ;
反应条件
1: H2 / Pd-C / ethanol 2: (i) aq. NaNO2, HCl, (ii) aq. HPF6, (iii) (heating) View Scheme
参考文献
Flaugh; Crowell; Clemens; Sawyer
Journal of Medicinal Chemistry, 1979 , vol. 22, # 1 p. 63 - 69
反应条件
copper(I) oxide; ammonium hydroxide T=140°C;
参考文献
Karrer; Strong
Helvetica Chimica Acta, 1935 , vol. 18, p. 1343,1347, 1348
参考文献
Karrer; Strong
Helvetica Chimica Acta, 1935 , vol. 18, p. 1343,1347, 1348
反应条件
1: H2 / Pd-C / ethanol 2: (i) aq. NaNO2, HCl, (ii) aq. HPF6, (iii) (heating) 3: Py*HCl / 150 - 220 °C View Scheme
参考文献
Flaugh; Crowell; Clemens; Sawyer
Journal of Medicinal Chemistry, 1979 , vol. 22, # 1 p. 63 - 69
反应条件
sodium hydroxide; tert-butyl alcohol in water Irradiation; Quantum yield;
参考文献
Sawaura, Masaki; Mukai, Toshio
Bulletin of the Chemical Society of Japan, 1981 , vol. 54, # 10 p. 3213 - 3214
反应条件
1: aqueous formaldehyde; concentrated aqueous HCl / Einleiten von HCl 2: palladium/charcoal; ethanol / Hydrogenation 3: concentrated aqueous hydrochloric acid / 145 °C View Scheme
参考文献
Matsukawa; Matsuno; Shirakawa
Yakugaku Zasshi, 1943 , vol. 63, p. 1,4
Chem.Abstr., 1950 , p. 7255
反应条件
1: 73 percent / potassium permanganate, sodium hydrogen carbonate / H2O / 4 h / Heating 2: 91 percent / BF3 / 12 h 3: 91 percent / hydrogen / 10percent Pd/C / CH2Cl2; ethanol / 12 h 4: 20percent H2SO4, sodium nitrite / H2O / 0 °C 5: KI / H2O / 2 h / 50 °C 6: 97 percent / Et3N, Pd(OAc)2, P(o-Tol)3 / dimethylformamide / 3 h / 100 °C 7: KOH / ethanol / 3 h / Heating View Scheme
参考文献
European Journal of Inorganic Chemistry, , # 5 p. 613 - 619
反应条件
1: KMnO4 / H2O / Heating 2: SOCl2 3: (i) Mg, (ii) H2SO4, AcOH View Scheme
参考文献
Julia,M.; Chastrette,F.
Bulletin de la Societe Chimique de France, 1962 , p. 2255 - 2261
反应条件
1.1: 99 percent / H2 / Pd/C / ethanol / 1 h
2.1: NaNO2; HCl / H2O / 1 h / 0 °C
2.2: 84 percent / KI / H2O / 12 h / 25 °C
View Scheme
参考文献
Iwashita, Masazumi; Fujii, Shinya; Ito, Shigeru; Hirano, Tomoya; Kagechika, Hiroyuki
Tetrahedron, 2011 , vol. 67, # 33 p. 6073 - 6082
