5-甲基-2-硝基苯甲醚合成路线 （共 55 条）
反应条件
sodium hydroxide; sulfur
参考文献
Khotinsky; Jacopson-Jacopmann
Chemische Berichte, 1909 , vol. 42, p. 3101
反应条件
1: H2 / Pd/C / 3 h / 20 °C
2: 76 percent / Cu(OAc)2 / CH2Cl2 / 2 h / 20 °C
3: 71 percent / DMF / Pd(OAc)2 / 0.02 h / microwave irradiation
View Scheme
参考文献
Chakraborty, Suchandra; Chattopadhyay, Gautam; Saha, Chandan
Journal of Heterocyclic Chemistry, 2013 , vol. 50, # 1 p. 91 - 98
反应条件
1.1: 99 percent / H2 / Pd/C / ethanol / 1 h
2.1: NaNO2; HCl / H2O / 1 h / 0 °C
2.2: 84 percent / KI / H2O / 12 h / 25 °C
3.1: 14 percent / Cu bronze / 5 h / 250 °C
4.1: 91 percent / BBr3 / CH2Cl2 / -78 - 25 °C
View Scheme
参考文献
Coleman; Guernon; Roland
Organic letters, 2000 , vol. 2, # 3 p. 277 - 280
反应条件
1: H2 / Pd-C / ethanol
2: (i) aq. NaNO2, HCl, (ii) aq. HPF6, (iii) (heating)
3: Py*HCl / 150 - 220 °C
4: (i) aq. NaNO2, H2SO4, AcOH, (ii) aq. HNO3
View Scheme
参考文献
Flaugh; Crowell; Clemens; Sawyer
Journal of Medicinal Chemistry, 1979 , vol. 22, # 1 p. 63 - 69
反应条件
1: H2 / Pd-C / ethanol
2: (i) aq. NaNO2, HCl, (ii) aq. HPF6, (iii) (heating)
3: Py*HCl / 150 - 220 °C
4: (i) aq. NaNO2, H2SO4, AcOH, (ii) aq. HNO3
5: K2CO3 / ethanol
View Scheme
参考文献
Flaugh; Crowell; Clemens; Sawyer
Journal of Medicinal Chemistry, 1979 , vol. 22, # 1 p. 63 - 69
