4-(2-(二乙基氨基)乙氧基)-苯胺合成路线 （共 16 条）
反应条件
hydrogen; palladium 10 on activated carbon in methanol
4 h;
参考文献
BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2004/39764 A1, 2004 ;
Location in patent: Page/Page column 83-84 ;
WO 2004/039764 A1
反应条件
hydrogenchloride in water
参考文献
The Boots Company PLC
Patent: US5464781 A1, 1995 ;
反应条件
1: sodium ethylate; ethanol
2: palladium/charcoal / Hydrogenation
View Scheme
参考文献
Chabrier et al.
Bulletin de la Societe Chimique de France, 1955 , p. 1353,1358
反应条件
hydrogen; palladium on activated charcoal in methanol
P=760 Torr; Ambient temperature;
参考文献
Sohda; Mizuno; Imamiya; Sugiyama; Fujita; Kawamatsu
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 10 p. 3580 - 3600
反应条件
hydrogenchloride in 1,4-dioxane
T=20°C; 12 h; Cooling with ice;
参考文献
Mooring, Suazette Reid; Liu, Jin; Liang, Zhongxing; Ahn, Jeffrey; Hong, Samuel; Yoon, Younghyoun; Snyder, James P.; Shim, Hyunsuk
ChemMedChem, 2013 , vol. 8, # 4 p. 622 - 632
反应条件
1: K2CO3 / dimethylformamide / 3 h / 80 °C
2: H2 / 10percent Pd/C / ethanol
View Scheme
参考文献
Wyatt, Paul G.; Bethell, Richard C.; Cammack, Nicholas; Charon, Daniel; Dodic, Nerina; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 10 p. 1657 - 1665
反应条件
1: 85 percent / dimethylformamide / 20 h
2: 25.0 g / H2 / Raney nickel / tetrahydrofuran
View Scheme
参考文献
Capps, David B.; Dunbar, James; Kesten, Suzanne R.; Shillis, Joan; Werbel, Leslie M.; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 26 p. 4770 - 4778
反应条件
1: 61.6 percent / NaH / dimethylsulfoxide / 0.5 h / 70 °C
2: hydrogen / 10percent Pd-C / methanol / 760 Torr / Ambient temperature
View Scheme
参考文献
Sohda; Mizuno; Imamiya; Sugiyama; Fujita; Kawamatsu
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 10 p. 3580 - 3600
反应条件
1: 61.6 percent / NaH / dimethylsulfoxide / 0.5 h / 70 °C
2: hydrogen / 10percent Pd-C / methanol / 760 Torr / Ambient temperature
View Scheme
参考文献
Sohda; Mizuno; Imamiya; Sugiyama; Fujita; Kawamatsu
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 10 p. 3580 - 3600
反应条件
1: caesium carbonate / N,N-dimethyl-formamide / 2.5 h / 100 °C / |Inert atmosphere
2: hydrogen; 5 palladium on charcoal / methanol / 4 h / 20 °C
View Scheme
参考文献
Pan, Xiaoyan; Wang, Fang; Zhang, Yanmin; Gao, Hongping; Hu, Zhigang; Wang, Sicen; Zhang, Jie
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 9 p. 2527 - 2534
