3-乙基-3-(4-硝基苯基)-2,6-哌啶二酮合成路线 （共 15 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol P=760 Torr; 1 h;
参考文献
Flaih, Nazar; Pham-Huy, Chuong; Galons, Herve
Tetrahedron Letters, 1999 , vol. 40, # 19 p. 3697 - 3698
参考文献
Achmatowicz, Osman; Malinowska, Iwona; Szechner, Barbara; Maurin, Jan K.
Tetrahedron, 1997 , vol. 53, # 23 p. 7917 - 7928
反应条件
potassium hydroxide in methanol; water
48 h;
参考文献
Achmatowicz, Osman; Malinowska, Iwona; Szechner, Barbara; Maurin, Jan K.
Tetrahedron, 1997 , vol. 53, # 23 p. 7917 - 7928
反应条件
sulfuric acid; nitric acid
T=-10 - 0°C; 2 h;
参考文献
Hartmann, Rolf W.; Batzl, Christine
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1362 - 1369
参考文献
Bushell, Simon M.; Crump, J. Paul; Lawrence, Nicholas J.; Pineau, Guillaume
Tetrahedron, 1998 , vol. 54, # 10 p. 2269 - 2274
反应条件
1: 53 percent / trimethylbenzylammoniumhydroxide (Triton B) / dioxane; methanol / 15 h / Heating
2: 59 percent / concd H2SO4, CH3CO2H / 6 h
3: 9 percent / concd H2SO4, 63percent aq. HNO3 / 2 h / -10 - 0 °C
View Scheme
参考文献
Hartmann, Rolf W.; Batzl, Christine
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1362 - 1369
反应条件
1: 73 percent / NaNH2 / benzene; toluene / 1 h / 80 °C
2: 53 percent / trimethylbenzylammoniumhydroxide (Triton B) / dioxane; methanol / 15 h / Heating
3: 59 percent / concd H2SO4, CH3CO2H / 6 h
4: 9 percent / concd H2SO4, 63percent aq. HNO3 / 2 h / -10 - 0 °C
View Scheme
参考文献
Hartmann, Rolf W.; Batzl, Christine
Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1362 - 1369
反应条件
1: 58 percent / NaH / dimethylformamide / 2 h / 0 °C
2: 1) NaH / 1) DMF, 0 deg C, 60 min, 2) DMF, 0 deg C, 0.5 h
3: 60 percent / polyphosphoric acid / 0.5 h / 180 °C
View Scheme
参考文献
Bushell, Simon M.; Crump, J. Paul; Lawrence, Nicholas J.; Pineau, Guillaume
Tetrahedron, 1998 , vol. 54, # 10 p. 2269 - 2274
反应条件
1: 96 percent / SOCl2 / Ambient temperature
2: 75 percent / KOH / acetonitrile / 0.25 h
3: 82 percent / polyphosphoric acid / 0.5 h / 180 °C
View Scheme
参考文献
Achmatowicz, Osman; Malinowska, Iwona; Szechner, Barbara; Maurin, Jan K.
Tetrahedron, 1997 , vol. 53, # 23 p. 7917 - 7928
反应条件
1: 75 percent / KOH / acetonitrile / 0.25 h
2: 82 percent / polyphosphoric acid / 0.5 h / 180 °C
View Scheme
参考文献
Achmatowicz, Osman; Malinowska, Iwona; Szechner, Barbara; Maurin, Jan K.
Tetrahedron, 1997 , vol. 53, # 23 p. 7917 - 7928
