3,3,5,5-四甲基-2,6-哌嗪二酮合成路线 （共 3 条）
反应条件
1: With sulfuric acid
T=5 - 100°C; 75 h;
2: With sodium hydroxide
pH=7; Cooling with ice;
参考文献
Stoller, Sven; Sicoli, Giuseppe; Baranova, Tatiana Y.; Bennati, Marina; Diederichsen, Ulf
Angewandte Chemie - International Edition, 2011 , vol. 50, # 41 p. 9743 - 9746
反应条件
anhydrous guanidine in N,N-dimethyl-formamide
T=50°C; 6 h;
参考文献
Wendelin, Winfried; Schramm, Hans-Wolfgang; Zmoelnig, Ilse
Monatshefte fuer Chemie, 1981 , vol. 112, p. 853 - 866
反应条件
ammonium hydroxide; ammonium chloride
7 h; Reflux;
参考文献
Francavilla, Charles; Turtle, Eric D.; Kim, Bum; O'Mahony, Donogh J.R.; Shiau, Timothy P.; Low, Eddy; Alvarez, Nichole J.; Celeri, Chris E.; D'Lima, Louisa; Friedman, Lisa C.; Ruado, Francis S.; Xu, Ping; Zuck, Meghan E.; Anderson, Mark B.; Najafi, Ramin; Jain, Rakesh K.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 10 p. 3029 - 3033
