2-氯-6-甲氧基-3-硝基吡啶合成路线 （共 13 条）
反应条件
in methanol; ethyl acetate
参考文献
Biogen, Inc.
Patent: US6306840 B1, 2001 ;
参考文献
Rutgerswerke Aktiengesellschaft
Patent: US4529800 A1, 1985 ;
反应条件
1: methanol With sodium hydride in toluene Inert atmosphere; 2: 2,6-dichloro-3-nitro-pyridine in toluene T=0 - 20°C; 16.5 h; Inert atmosphere; regioselective reaction;
参考文献
Yap, Jeremy L.; Hom, Kellie; Fletcher, Steven
Tetrahedron Letters, 2011 , vol. 52, # 32 p. 4172 - 4176
反应条件
1: With hydrogenchloride; water T=90°C; 3 h; 2: With sodium hydroxide in water pH=5;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2009/24821 A2, 2009 ;
Location in patent: Page/Page column 142-143 ;
WO 2009/024821 A2
反应条件
hydrogen in tetrahydrofuran T=37°C; P=2250.23 Torr; 12 h; chemoselective reaction;
参考文献
Kasparian, Annie J.; Savarin, Cecile; Allgeier, Alan M.; Walker, Shawn D.
Journal of Organic Chemistry, 2011 , vol. 76, # 23 p. 9841 - 9844
反应条件
1: aq. NH3 / 72 h 2: HBr; AcOH / 60 °C 3: POCl3 / 100 °C View Scheme
参考文献
McClure, Kelly J.; Huang, Liming; Arienti, Kristen L.; Axe, Frank U.; Brunmark, Anders; Blevitt, Jon; Guy Breitenbucher
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 7 p. 1924 - 1928
反应条件
1: With potassium fluoride; copper(l) iodide in N,N-dimethyl-formamide T=125°C; 13 h; 2: With ammonia; ammonium chloride in water; N,N-dimethyl-formamide T=20°C; 1.5 h;
参考文献
EP2128158 A1, ;
Page/Page column 20-21 ;
EP 2128158 A1
反应条件
copper in isobutyramide T=20 - 100°C; 8 h;
参考文献
WO2004/62665 A1, ;
Page/Page column 35 ;
WO 2004/062665 A1
反应条件
ammonia in methanol T=65°C; 18 h;
参考文献
EISAI CO., LTD.
Patent: WO2005/103049 A1, 2005 ;
Location in patent: Page/Page column 102-103 ;
反应条件
in sulfolane T=135°C; 0.75 h; Microwave irradiation;
参考文献
Journal of Heterocyclic Chemistry, , vol. 46, # 6 p. 1125 - 1131
