3,5-双(甲氧基羰基)苯甲酸合成路线 （共 8 条）
反应条件
dimethylsulfide borane complex in tetrahydrofuran T=27°C; Reduction; 24 h;
参考文献
Dimick, Sarah M.; Powell, Steven C.; McMahon, Stephen A.; Moothoo, Davina N.; Naismith, James H.; Toone, Eric J.
Journal of the American Chemical Society, 1999 , vol. 121, # 44 p. 10286 - 10296
反应条件
1: 88 percent / borane-methyl sulfide / tetrahydrofuran / 24 h / 27 °C 2: 93 percent / SOCl2 / 1 h / Heating View Scheme
参考文献
Dimick, Sarah M.; Powell, Steven C.; McMahon, Stephen A.; Moothoo, Davina N.; Naismith, James H.; Toone, Eric J.
Journal of the American Chemical Society, 1999 , vol. 121, # 44 p. 10286 - 10296
反应条件
1: With water; sodium hydroxide in methanol
18 h;
2: With hydrogenchloride in water
参考文献
ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY; WAGNER, Carl E.; JURUTKA, Peter W.; MARSHALL, Pamela A.; VAN DER VAART, Arjan
Patent: WO2011/103321 A1, 2011 ;
Location in patent: Page/Page column 20-21 ;
反应条件
1: 84 percent / K2CO3 / dimethylformamide / 14 h / 40 °C
2: 49 percent / LiOH / tetrahydrofuran; H2O / 2.5 h / 20 °C
View Scheme
参考文献
Kahnberg, Pia; Lager, Erik; Rosenberg, Celia; Schougaard, Jette; Camet, Linda; Sterner, Olov; Nielsen, Elsebet stergaard; Nielsen, Mogens; Liljefors, Tommy
Journal of Medicinal Chemistry, 2002 , vol. 45, # 19 p. 4188 - 4201
反应条件
sodium hydroxide in methanol
18 h; Heating; Title compound not separated from byproducts;
参考文献
Wilson, Andrew J.; Van Gestel, Jeroen; Sijbesma, Rint P.; Meijer
Chemical Communications, 2006 , # 42 p. 4404 - 4406
反应条件
1: sulfuric acid / methanol / 24 h / |Reflux
2: sodium hydroxide / methanol / 12 h / |Reflux
View Scheme
参考文献
Wang, Daoliang; Huang, Youju; Li, Junjun; Xu, Lu; Chen, Mingming; Tao, Jiaojiao; Li, Liangbin
Chemistry - A European Journal, 2013 , vol. 19, # 2 p. 685 - 690
反应条件
1: 49 percent / 1 M lithium triethylborohydride / tetrahydrofuran
2: 90 percent / PBr3
View Scheme
参考文献
Engel; Burris; Slate; Erickson
Tetrahedron, 1993 , vol. 49, # 39 p. 8761 - 8770
反应条件
in tetrahydrofuran
96 h; Heating;
参考文献
Wilson, Andrew J.; Masuda, Mitsutoshi; Sijbesma, Rint P.; Meijer
Angewandte Chemie - International Edition, 2005 , vol. 44, # 15 p. 2275 - 2279
