3-(4-羧基苯基)丙酸合成路线 （共 19 条）
反应条件
1: sodium; alcohol / man verseift den Diaethylester mit Natronlauge 2: 160 °C 3: diluted nitric acid View Scheme
参考文献
Widman
Chemische Berichte, 1889 , vol. 22, p. 2279
Chemische Berichte, 1890 , vol. 23, p. 3086
反应条件
1: zinc dust; glacial acetic acid 3: 240 °C View Scheme
参考文献
Titley
Journal of the Chemical Society, 1928 , p. 2576
反应条件
2: 240 °C View Scheme
参考文献
Titley
Journal of the Chemical Society, 1928 , p. 2576
参考文献
Titley
Journal of the Chemical Society, 1928 , p. 2576
参考文献
Widman
Chemische Berichte, 1889 , vol. 22, p. 2279
Chemische Berichte, 1890 , vol. 23, p. 3086
反应条件
sodium chloride; AlCl3, aluminium chloride T=180°C; 1 h; Neat (no solvent);
参考文献
Gruenenthal GmbH
Patent: US2010/249095 A1, 2010 ;
Location in patent: Page/Page column 68-69 ;
US 20100249095 A1
反应条件
1.1: AlCl3, aluminium chloride; sodium chloride / 12 h / 190 °C
1.2: cooling with ice
2.1: sulfuric acid / 4 h / 0 °C / Reflux
View Scheme
参考文献
GRUENENTHAL GmbH
Patent: US2012/71461 A1, 2012 ;
反应条件
1: concentrated sulfuric acid; fuming nitric acid
2: ferrosulfate; ammonia
View Scheme
参考文献
Widman
Chemische Berichte, 1889 , vol. 22, p. 2279
Chemische Berichte, 1890 , vol. 23, p. 3086
反应条件
sulfuric acid in ethanol; water
参考文献
ELI LILLY AND COMPANY
Patent: EP846687 A1, 1998 ;
