3-(4-羟基甲基苯基)-1-丙醇合成路线 （共 14 条）
反应条件
oxoammonium salt in water; acetonitrile T=20°C; 8 h;
参考文献
Qiu, Joseph C.; Pradhan, Priya P.; Blanck, Nyle B.; Bobbitt, James M.; Bailey, William F.
Organic Letters, 2012 , vol. 14, # 1 p. 350 - 353
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=70°C; 1.36667 h;
参考文献
ACTELION PHARMACEUTICALS LTD.
Patent: US2008/194670 A1, 2008 ;
Location in patent: Page/Page column 21 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
T=20°C; 1 h;
2: With hydrogen; platinum on activated charcoal in ethanol
T=20°C; P=760.051 Torr; 3 h; Further stages.;
参考文献
Tanaka, Ken; Shibata, Yu; Suda, Takeshi; Hagiwara, Yuji; Hirano, Masao
Organic Letters, 2007 , vol. 9, # 7 p. 1215 - 1218
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=0 - 20°C; Inert atmosphere;
参考文献
Kuwano, Satoru; Harada, Shingo; Oriez, Raphael; Yamada, Ken-Ichi
Chemical Communications, 2012 , vol. 48, # 1 p. 145 - 147
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=20°C; 1 h; Title compound not separated from byproducts.;
参考文献
Tanaka, Ken; Shibata, Yu; Suda, Takeshi; Hagiwara, Yuji; Hirano, Masao
Organic Letters, 2007 , vol. 9, # 7 p. 1215 - 1218
反应条件
1.1: Pd(OAc)2; NaOAc / 1-methyl-pyrrolidin-2-one / 120 °C
1.2: 1-methyl-pyrrolidin-2-one / 2 h / 135 °C
2.1: LiAlH4 / tetrahydrofuran / 1 h / 20 °C
2.2: 0.73 g / H2 / Pt/C / ethanol / 3 h / 20 °C / 760.05 Torr
View Scheme
参考文献
Tanaka, Ken; Shibata, Yu; Suda, Takeshi; Hagiwara, Yuji; Hirano, Masao
Organic Letters, 2007 , vol. 9, # 7 p. 1215 - 1218
反应条件
1: H2; DIPEA / palladium monocarbide / ethanol
2: LiAlH4 / tetrahydrofuran
View Scheme
参考文献
Actelion Pharmaceuticals Ltd.
Patent: EP1863475 B1, 2011 ;
反应条件
1: DIPEA / palladium monocarbide / ethanol
2: LiAlH4 / tetrahydrofuran
View Scheme
参考文献
Actelion Pharmaceuticals Ltd.
Patent: EP1863475 B1, 2011 ;
反应条件
water; potassium hydroxide in methanol
参考文献
Dinda; Mohanta; Ghosh; Sato; Harigaya
Journal of the Indian Chemical Society, 2010 , vol. 87, # 7 p. 829 - 831
反应条件
thionyl chloride; benzotriazol-1-ol; potassium iodide in dichloromethane; N,N-dimethyl-formamide
T=20°C; 16 h;
参考文献
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
Patent: US2011/312930 A1, 2011 ;
Location in patent: Page/Page column 55 ;
US 20110312930 A1
