1-哌啶-1-基环己烷甲腈合成路线 （共 34 条）
反应条件
1,4-diaza-bicyclo[2.2.2]octane; Hg(II) trifluoroacetate; sodium cyanoborohydride in methanol 24 h; Ambient temperature;
参考文献
Tetrahedron, , vol. 52, # 33 p. 10835 - 10840
反应条件
aluminium hydride in tetrahydrofuran 20 h; Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 36, # 16 p. 2311 - 2320
反应条件
in tetrahydrofuran; diethyl ether T=0°C; Inert atmosphereReflux;
参考文献
Letters in Drug Design and Discovery, , vol. 7, # 2 p. 79 - 87
反应条件
1: 1.) Mg / 1.) benzene, ether, 2.) reflux, 4 h 2: 71 percent / dimethylformamide / 72 h / 120 °C 3: 76 percent / 30percent H2O2, K2CO3 / acetone; H2O / 3 h / 40 °C 4: 66 percent / CH3ONa, bromine / methanol; dioxane / 0.5 h / 40 °C 5: aq. KOH / methanol / 6 h / 60 °C View Scheme
参考文献
Johnson, Peter Y.; Pan, Robert; Wen, Jing Quan; Halfman, Clarke J.
Journal of Organic Chemistry, 1981 , vol. 46, # 10 p. 2049 - 2054
反应条件
1: 89 percent / diethyl ether / 4 h / Ambient temperature 2: concd. HCl / Ambient temperature View Scheme
参考文献
Iorio, Maria A.; Tomassini, Lamberto; Mattson, Mariena V.; George, Clifford; Jacobson, Arthur E.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 8 p. 2615 - 2623
反应条件
magnesium 1.) ether, 2.) reflux, 16 h; Yield given. Multistep reaction;
参考文献
Ilagouma, A. T.; Dornand, J.; Liu, C. F.; Zenone, F.; Mani, J. C.; Kamenka, J. M.
European Journal of Medicinal Chemistry, 1990 , vol. 25, # 7 p. 609 - 615
反应条件
magnesium
1.) Et2O, THF, reflux, 2 h; 2.) THF, Et2O, reflux, 1 h; Yield given. Multistep reaction;
参考文献
Jones; Beaver; Schmoeger; et al.
Journal of Organic Chemistry, 1981 , vol. 46, # 16 p. 3330 - 3333
反应条件
magnesium
1.) ether, benzene, reflux, 2.) reflux, 4 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Johnson, Peter Y.; Wen, Jing Quan
Journal of Organic Chemistry, 1981 , vol. 46, # 13 p. 2767 - 2771
反应条件
in tetrahydrofuran
6 h; Heating;
参考文献
Fotadar, Upinder
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1981 , vol. 20, # 11 p. 1006 - 1007
反应条件
magnesium
1.) ether, RT, 2.) ether, reflux, 12 h; Multistep reaction;
参考文献
Ilagouma, AT; Maurice, T; Duterte-Boucher, D; Coderc, E; Vignon, J; et al.
European Journal of Medicinal Chemistry, 1993 , vol. 28, # 5 p. 377 - 385
