3-溴-4-羟基苯基乙酸合成路线 （共 11 条）
反应条件
nitrogen; boron tribromide in dichloromethane
参考文献
AXYS PHARMACEUTICALS, INC.
Patent: WO2004/62661 A1, 2004 ;
Location in patent: Page/Page column 28 ;
WO 2004/062661 A1
反应条件
bromine in acetic acid 3 h; Heating;
参考文献
Pachaly, Peter; Schaefer, Michael
Archiv der Pharmazie (Weinheim, Germany), 1989 , vol. 322, p. 483 - 487
反应条件
1: With Oxonereg;; sodium bromide in water; acetone T=20°C; 0.05 h; 2: With water; sodium hydroxide in tetrahydrofuran T=20°C; 14 h; 3: With acetic acid in tetrahydrofuran; water pH=3 - 4;
参考文献
Kang, Dong Wook; Kim, Yong Soo; Lim, Kwang Su; Kim, Myeong Seop; Pearce, Larry V.; Pavlyukovets, Vladimir A.; Tao, Andy K.; Lang-Kuhs, Krystle A.; Blumberg, Peter M.; Lee, Jeewoo
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 22 p. 8092 - 8105
反应条件
hydrogen iodide; iodine in acetic acid Heating;
参考文献
Sugita, Shin-Ichi; Toda, Susumu; Yoshiyasu, Takashi; Teraji, Tsutomu
Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals, 1993 , vol. 237, p. 399 - 406
反应条件
1: aq. NaOH 2: I2, P, 57percent HI / aq. acetic acid / Heating View Scheme
参考文献
Sugita, Shin-Ichi; Toda, Susumu; Yoshiyasu, Takashi; Teraji, Tsutomu
Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals, 1993 , vol. 237, p. 399 - 406
反应条件
bromine; urea 1.) AcOH, 60 h; 2.) 140 degC, 2 h; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given;
参考文献
D'Ambrosio; Guerriero; Pietra
Helvetica Chimica Acta, 1984 , vol. 67, # 6 p. 1484 - 1492
反应条件
bromine; urea 1.) AcOH, 60 h; 2.) 140 degC, 2 h; Yield given. Multistep reaction. Further byproducts given. Yields of byproduct given;
参考文献
D'Ambrosio; Guerriero; Pietra
Helvetica Chimica Acta, 1984 , vol. 67, # 6 p. 1484 - 1492
参考文献
Kondo et al.
Itsuu Kenkyusho Nempo, 1958 , # 9 p. 1,4; engl. Ref. S. 59, 62
Chem.Abstr., 1960 , p. 1399
反应条件
1: hydrogen chloride 2: aq. NaOH solution 3: ethanolic KOH-solution View Scheme
参考文献
Kondo; Uyeo
Yakugaku Zasshi, 1933 , vol. 53, p. 557,563; dtsch. Ref. S. 92
Chem.Abstr., 1933 , p. 4223
反应条件
thionyl chloride T=20°C; 2 h;
参考文献
AXYS PHARMACEUTICALS, INC.
Patent: WO2004/62661 A1, 2004 ;
Location in patent: Page/Page column 28 ;
WO 2004/062661 A1
