1: With hydrogenchloride; iron in methanol; water
T=20 - 60°C; 2 h;
2: With sodium hydrogencarbonate in tetrahydrofuran; methanol; water; ethyl acetate
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED; TAKEDA SAN DIEGO, INC.
Patent: WO2007/75847 A2, 2007 ;
Location in patent: Page/Page column 109-111 ;
WO 2007/075847 A2
