(2S,4E,7R)-7-[4-甲氧基-3-(3-甲氧基丙氧基)苄基]-8-甲基-2-异丙基-4-壬烯酸甲酯合成路线 （共 12 条）
反应条件
1.1: potassium hydroxide; water / 1,4-dioxane / 24 h / Reflux 1.2: 0 - 5 °C 2.1: hydrogenchloride / anhydrous dichloroethane; water / 0 - 5 °C / pH 2.5 2.2: 14.25 h / 0 - 30 °C 3.1: N-bromosuccinmide; phosphoric acid / water; tetrahydrofuran / 1.25 h / 0 - 5 °C 4.1: sodium azide / ethylene glycol / 20 h / 80 - 85 °C 5.1: triethylamine; 2-hydroxy-pyridine / 16 h / 85 - 90 °C 6.1: hydrogen; ethanolamine / palladium 10 on activated carbon / isopropyl alcohol / 3 h View Scheme
反应条件
1.1: potassium hydroxide; water / 1,4-dioxane / 24 h / Reflux 1.2: 0 - 5 °C 2.1: hydrogenchloride / anhydrous dichloroethane; water / 0 - 5 °C / pH 2.5 2.2: 14.25 h / 0 - 30 °C 3.1: N-bromosuccinmide; phosphoric acid / water; tetrahydrofuran / 1.25 h / 0 - 5 °C 4.1: sodium azide / ethylene glycol / 20 h / 80 - 85 °C 5.1: triethylamine; 2-hydroxy-pyridine / 16 h / 85 - 90 °C View Scheme
参考文献
MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; THIRUMALAI RAJAN, Srinivasan; ESWARAIAH, Sajja; VENKAT REDDY, Ghojala; RAMA SUBBA REDDY, Karamala; SAHADEVA REDDY, Maramreddy
Patent: WO2011/148392 A1, 2011 ;
