反应条件
1: N-bromosuccinmide; dibenzoyl peroxide / tetrachloromethane / 30 h / |Reflux 2: morpholine / 1 h / 60 °C 3: [palladium(II)(bis(triphenylphosphanyl))dichloride]; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 1.5 h / 20 °C 4: ammonia / ethanol / 2 h / 80 °C / |Sealed tube View Scheme
参考文献
Horne, Daniel B.; Tamayo, Nuria A.; Bartberger, Michael D.; Bo, Yunxin; Clarine, Jeffrey; Davis, Carl D.; Gore, Vijay K.; Kaller, Matthew R.; Lehto, Sonya G.; Ma, Vu V.; Nishimura, Nobuko; Nguyen, Thomas T.; Tang, Phi; Wang, Weiya; Youngblood, Beth D.; Zhang, Maosheng; Gavva, Narender R.; Monenschein, Holger; Norman, Mark H.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 7 p. 2989 - 3004