1: 1.) NaH / 1.) THF, 90 min, 2.) THF, 30 min 2: lithium triethylborohydride / tetrahydrofuran / 0.5 h 3: potassium carbonate / methanol; tetrahydrofuran / 2.5 h View Scheme

1: 1.) NaH / 1.) DME, RT, 1 h, 2.) DME, a) 0 deg C, 30 min, b) RT, 2 h 2: 52 percent / lithium tri-sec-butylborohydride (lithium selectride) / tetrahydrofuran; diethyl ether / 1 h / -78 - -75 °C 3: 78.4 percent / H2, 1 M NaOH / 10percent Pd/C / ethanol / 6 h 4: 85 percent / K2CO3 / methanol / 6 h / Ambient temperature 5: 65 percent / diisobutylaluminium hydride (DIBAL) / toluene; tetrahydrofuran / 1 h / -80 - -72 °C 6: 1.) t-BuOK / 1.) THF, RT, 30 min, 2.) THF, -15 to -10 deg C, 4 h View Scheme

1: 1.) NaH / 1.) THF, 90 min, 2.) THF, 30 min 2: lithium triethylborohydride / tetrahydrofuran / 0.5 h 3: potassium carbonate / methanol; tetrahydrofuran / 2.5 h View Scheme

1: 1.) NaH / 1.) DME, RT, 1 h, 2.) DME, a) 0 deg C, 30 min, b) RT, 2 h 2: 33.1 percent / lithium tri-sec-butylborohydride (lithium selectride) / tetrahydrofuran; diethyl ether / 1 h / -78 - -75 °C 3: 65 percent / H2, 1 M NaOH / 10percent Pd/C / ethanol / 6 h 4: 83.6 percent / K2CO3 / methanol / 6 h / Ambient temperature 5: 83 percent / diisobutylaluminium hydride (DIBAL) / toluene; tetrahydrofuran / 1 h / -80 - -72 °C View Scheme

1: 1.) NaH / 1.) DME, RT, 1 h, 2.) DME, a) 0 deg C, 30 min, b) RT, 2 h 2: 52 percent / lithium tri-sec-butylborohydride (lithium selectride) / tetrahydrofuran; diethyl ether / 1 h / -78 - -75 °C 3: 78.4 percent / H2, 1 M NaOH / 10percent Pd/C / ethanol / 6 h 4: 85 percent / K2CO3 / methanol / 6 h / Ambient temperature 5: 65 percent / diisobutylaluminium hydride (DIBAL) / toluene; tetrahydrofuran / 1 h / -80 - -72 °C 6: 1.) t-BuOK / 1.) THF, RT, 30 min, 2.) THF, -15 to -10 deg C, 4 h 7: 38 percent / DBU / acetone / 4 h / Ambient temperature View Scheme

1: 1.) NaH / 1.) DME, RT, 1 h, 2.) DME, a) 0 deg C, 30 min, b) RT, 2 h 2: 33.1 percent / lithium tri-sec-butylborohydride (lithium selectride) / tetrahydrofuran; diethyl ether / 1 h / -78 - -75 °C 3: 65 percent / H2, 1 M NaOH / 10percent Pd/C / ethanol / 6 h 4: 83.6 percent / K2CO3 / methanol / 6 h / Ambient temperature View Scheme

sodium hydride in ethylene glycol dimethyl ether T=0 - 20°C; Yield given;

1: dimethyl [3-(3-(trifluoromethyl)phenoxy)-2-oxopropyl]phosphonate With potassium tert-butylate in tetrahydrofuran T=0 - 5°C; 2: With zinc(II) chloride in tetrahydrofuran T=15 - 20°C; 1 h; 3: (1S,5R,6R,7R)-6-formyl-7-lt;(4-phenylbenzoyl)oxygt;-2-oxabicyclolt;3.3.0gt;octan-3-one in tetrahydrofuran; dichloromethane T=5 - 10°C;

sodium hydride 1.) THF, 90 min, 2.) THF, 30 min; Yield given. Multistep reaction;

1: 1.) NaH / 1.) DME, RT, 1 h, 2.) DME, a) 0 deg C, 30 min, b) RT, 2 h 2: 33.1 percent / lithium tri-sec-butylborohydride (lithium selectride) / tetrahydrofuran; diethyl ether / 1 h / -78 - -75 °C 3: 65 percent / H2, 1 M NaOH / 10percent Pd/C / ethanol / 6 h 4: 83.6 percent / K2CO3 / methanol / 6 h / Ambient temperature 5: 83 percent / diisobutylaluminium hydride (DIBAL) / toluene; tetrahydrofuran / 1 h / -80 - -72 °C 6: 1.) t-BuOK / 1.) THF, RT, 30 min, 2.) THF, -15 to -10 deg C, 4 h View Scheme