1: 1,4-Dichloro-2-butyne; methyl iodide With Iron (III) nitrate nonahydrate; ammonia; sodium
T=-40°C; 3.5 h;
2: formaldehyd With sodium amide in tetrahydrofuran
T=-40°C; 3.5 h;
3: With ammonium chloride in tetrahydrofuran
参考文献
Bowling, Nathan P.; Burrmann, Nicola J.; Halter, Robert J.; Hodges, Jonathan A.; McMahon, Robert J.
Journal of Organic Chemistry, 2010 , vol. 75, # 19 p. 6382 - 6390
hydroxylamine hydrochloride; N-butylamine; copper(l) chloride in water
Cadiot-Chodkiewicz reaction;
参考文献
Bowling, Nathan P.; Burrmann, Nicola J.; Halter, Robert J.; Hodges, Jonathan A.; McMahon, Robert J.
Journal of Organic Chemistry, 2010 , vol. 75, # 19 p. 6382 - 6390
sodium hydroxide in ethanol
T=45 - 50°C; 5 h; also without aq. NaOH in THF; Product distribution;
参考文献
Khrimyan, A. P.; Karapetyan, A. V.; Badanyan, Sh. O.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1984 , vol. 20, # 2 p. 189 - 196
Khimiya Geterotsiklicheskikh Soedinenii, 1984 , vol. 20, # 2 p. 230 - 238
