2-(四氢-2H-吡喃-2-基)乙醇合成路线 （共 7 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
T=0°C; 2 h;
2: With sodium hydroxide in tetrahydrofuran
参考文献
Berthel, Steven Joseph; Chen, Li; Corbett, Wendy Lea; Feng, LiChun; Haynes, Nancy-Ellen; Kester, Robert Francis; So, Sung-Sau; Tilley, Jefferson Wright
Patent: US2011/144105 A1, 2011 ;
Location in patent: Page/Page column 49 ;
反应条件
1: With sodium tetrahydroborate in ethanol
T=50°C; 2 h;
2: With hydrogenchloride; ethanol; water
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/101867 A1, 2008 ;
Location in patent: Page/Page column 90 ;
反应条件
tri-isobutyl aluminium in hexane
1.) RT, 30 min, 2.) 60 deg C, 5 h;
参考文献
Menicagli, R.; Malanga, C.; Dell'Innocenti, M.; Lardicci, L.
Journal of Organic Chemistry, 1987 , vol. 52, # 26 p. 5700 - 5704
反应条件
1: 78 percent / 16 h / 25 °C
2: 95 percent / aq. NaOH, tetra-n-butylammonium acid sulfate(TBAS) / benzene / 6 h / 50 °C
3: 77 percent / Al-i-Bu3 / hexane / 1.) RT, 30 min, 2.) 60 deg C, 5 h
View Scheme
参考文献
Menicagli, R.; Malanga, C.; Dell'Innocenti, M.; Lardicci, L.
Journal of Organic Chemistry, 1987 , vol. 52, # 26 p. 5700 - 5704
反应条件
1: 95 percent / aq. NaOH, tetra-n-butylammonium acid sulfate(TBAS) / benzene / 6 h / 50 °C
2: 77 percent / Al-i-Bu3 / hexane / 1.) RT, 30 min, 2.) 60 deg C, 5 h
View Scheme
参考文献
Menicagli, R.; Malanga, C.; Dell'Innocenti, M.; Lardicci, L.
Journal of Organic Chemistry, 1987 , vol. 52, # 26 p. 5700 - 5704
反应条件
1: 60 percent / NaH / tetrahydrofuran / -78 °C
2: 68 percent / LiAlH4 / diethyl ether / 0 °C
View Scheme
参考文献
Kar, Paramita; Rao; Nagaiah; Gurjar
Journal of the Indian Chemical Society, 2005 , vol. 82, # 1 p. 52 - 54
反应条件
1: 64 percent / HCl / methanol / 20 °C
2: 60 percent / NaH / tetrahydrofuran / -78 °C
3: 68 percent / LiAlH4 / diethyl ether / 0 °C
View Scheme
参考文献
Kar, Paramita; Rao; Nagaiah; Gurjar
Journal of the Indian Chemical Society, 2005 , vol. 82, # 1 p. 52 - 54
