2-异丙基-3-[4-甲氧基-3-(3-甲氧基丙氧基)苯基]丙烯酸合成路线 （共 4 条）
反应条件
sodium hydroxide in water; toluene T=80 - 115°C; 6 h; Industry scale;
参考文献
BASF AKTIENGESELLSCHAFT
Patent: WO2006/97314 A1, 2006 ;
Location in patent: Page/Page column 30 ;
反应条件
bis(1,5-cyclooctadiene)-rhodium(I) tetrafluoroborate; C23H20NO2P; hydrogen; triphenylphosphine in water; isopropyl alcohol
T=55°C; P=60006 Torr; 18 h; Autoclave; Reagent/catalystSolventPressureTemperature;
参考文献
Boogers, Jeroen A. F.; Felfer, Ulfried; Kotthaus, Martina; Lefort, Laurent; Steinbauer, Gerhard; De Vries, Andre H. M.; De Vries, Johannes G.
Organic Process Research and Development, 2007 , vol. 11, # 3 p. 585 - 591
反应条件
hydrogen in methanol
T=20°C; P=37503.8 Torr;
参考文献
SOLVIAS AG
Patent: WO2007/116081 A1, 2007 ;
Location in patent: Page/Page column 41-43 ;
反应条件
1: triethylamine; thionyl chloride / dichloromethane / 0.5 h / 0 °C
2: dichloromethane / 20 °C
View Scheme
参考文献
Woodmansee, David H.; Mueller, Marc-Andre; Troendlin, Lars; Hoermann, Esther; Pfaltz, Andreas
Chemistry - A European Journal, 2012 , vol. 18, # 43 p. 13780 - 13786
