1: 71 percent / K2CO3 / dimethylformamide / 1.5 h / 100 °C 2: 1.) Mg / 1.) THF, 40 deg C, 40 min, 2.) RT, overnight View Scheme

sodium hydroxide

palladium 10 on activated carbon; potassium hydroxide T=150°C; Suzuki-Miyaura Coupling; 0.5 h; Microwave irradiationInert atmosphere; Reagent/catalyst;

sodium hydroxide; dihydrogen peroxide in water 0.5 h; Ambient temperature;

1: 86 percent / Br2, NaOAc / acetic acid / 0.5 h / Ambient temperature 2: 89 percent / H2O2, NaOH / H2O / 0.5 h / Ambient temperature View Scheme

1: 71 percent / K2CO3 / dimethylformamide / 1.5 h / 100 °C 2: 1.) Mg / 1.) THF, 40 deg C, 40 min, 2.) RT, overnight 3: 87 percent / pyridine, SOCl2 / toluene / 3 h / 60 °C 4: 46 percent / POCl3 / 7 h / 100 °C 5: 61 percent / K2CO3 / dimethylformamide / 7 h / 100 °C View Scheme

1: 71 percent / K2CO3 / dimethylformamide / 1.5 h / 100 °C 2: 1.) Mg / 1.) THF, 40 deg C, 40 min, 2.) RT, overnight 3: 87 percent / pyridine, SOCl2 / toluene / 3 h / 60 °C 4: 46 percent / POCl3 / 7 h / 100 °C 5: 60 percent / ethanol. NH3 / 10 h / 110 °C View Scheme