甲基1-乙酰基环丙烷羧酸酯合成路线 （共 7 条）
反应条件
1: With water; sodium hydroxide in methanol T=20°C; 24 h; 2: in methanol
参考文献
Takeda Pharmaceutical Company Limited
Patent: EP2530078 A1, 2012 ;
Location in patent: Page/Page column 160 ;
反应条件
potassium carbonate in acetone
16 h; Reflux;
参考文献
Beaudegnies, Renaud; De Mesmaeker, Alain; Mallinger, Aurelie; Baalouch, Myriam; Goetz, Andre
Tetrahedron Letters, 2010 , vol. 51, # 20 p. 2741 - 2744
反应条件
hydrogenchloride; potassium iodide; potassium carbonate in N,N-dimethyl acetamide
参考文献
Tanaka, Hiroki; Pan, Li Rui; Ikura, Kiyoshi
Patent: US2003/65212 A1, 2003 ;
反应条件
potassium carbonate; 18-crown-6 ether in dichloromethane
48 h; Ambient temperature;
参考文献
Lavoisier, Tania; Rodriguez, Jean
Synthetic Communications, 1996 , vol. 26, # 3 p. 525 - 530
反应条件
potassium carbonate; 18-crown-6 ether in butanone
3 h; Heating;
参考文献
Lavoisier, Tania; Rodriguez, Jean
Synthetic Communications, 1996 , vol. 26, # 3 p. 525 - 530
反应条件
potassium carbonate in acetone
9 h; Heating;
参考文献
Lavoisier, Tania; Rodriguez, Jean
Synthetic Communications, 1996 , vol. 26, # 3 p. 525 - 530
反应条件
copper(I) oxide in benzene
T=90°C; 24 h;
参考文献
Saegusa,T. et al.
Bulletin of the Chemical Society of Japan, 1972 , vol. 45, p. 1884 - 1888
