6-氟-3,4-二氢-1(2H)-喹啉羧醛合成路线 (共 3 条)
反应条件
hydrogenchloride 1 h; Heating;
参考文献
Zakrzewska; Kolehmainen; Osmialowski; Gawinecki
Journal of Fluorine Chemistry, 2001 , vol. 111, # 1 p. 1 - 10
反应条件
1: tert-butyl 6-fluoro-3,4-dihydroquinoline-1(2H)-carboxylate With trifluoroacetic acid in dichloromethane
2: formic acid With acetic anhydride
T=60°C; 1 h;
参考文献
AstraZeneca AB; NPS PHARMACEUTICALS
Patent: US2007/32469 A1, 2007 ;
Location in patent: Page/Page column 30; 36 ;
US 20070032469 A1
反应条件
sodium formate
33 h; Heating;
参考文献
Zakrzewska; Kolehmainen; Osmialowski; Gawinecki
Journal of Fluorine Chemistry, 2001 , vol. 111, # 1 p. 1 - 10