5-甲基-2-硝基苯甲酰氯合成路线 （共 14 条）
反应条件
1: CHCl3 / 1 h / Heating 2: stannous chloride / HCl / 24 h 3: 5 h / Heating View Scheme
参考文献
Plescia; Diadone; Raffa; Bajardi; Caruso; Cutuli; Amico-Roxas
Farmaco, 1992 , vol. 47, # 4 p. 465 - 475
反应条件
1: CHCl3 / 1 h / Heating 2: stannous chloride / HCl / 24 h 3: 5 h / Heating View Scheme
参考文献
Plescia; Diadone; Raffa; Bajardi; Caruso; Cutuli; Amico-Roxas
Farmaco, 1992 , vol. 47, # 4 p. 465 - 475
反应条件
1: CHCl3 / 1 h / Heating 2: stannous chloride / HCl / 24 h 3: 5 h / Heating View Scheme
参考文献
Plescia; Diadone; Raffa; Bajardi; Caruso; Cutuli; Amico-Roxas
Farmaco, 1992 , vol. 47, # 4 p. 465 - 475
反应条件
1: ammonium hydroxide / acetonitrile / 8 h / |Reflux 2: tin(ll) chloride; hydrogenchloride / 25 h / 5 °C View Scheme
参考文献
Raffa, Demetrio; Maggio, Benedetta; Raimondi, Maria Valeria; Cusimano, Maria Grazia; Amico, Giandomenico; Carollo, Anna; Conaldi, Pier Giulio; Bai, Ruoli; Hamel, Ernest; Daidone, Giuseppe
European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 427 - 435
反应条件
2: DIBAL-H / CH2Cl2 / 0.75 h / -78 °C 3: NaN3 / hexamethylphosphoric acid triamide / Ambient temperature View Scheme
参考文献
Kamal, Ahmed; Reddy, B.S. Praveen; Reddy, B.S. Narayan
Tetrahedron Letters, 1996 , vol. 37, # 37 p. 6803 - 6806
反应条件
1: (i) Mg, Et2O, (ii) /BRN= 2102443/, Et2O, (iii) aq. H2SO4, AcOH 2: Sn, aq. HCl / Heating View Scheme
参考文献
Doppler,T. et al.
Helvetica Chimica Acta, 1979 , vol. 62, p. 271 - 303
反应条件
phosphorus pentachloride
参考文献
Giacalone
Gazzetta Chimica Italiana, 1935 , vol. 65, p. 1127,1136
反应条件
1: NEt3 / CH2Cl2 / 20 °C
2: SnCl2*2H2O / ethyl acetate / Heating
View Scheme
参考文献
Chou, Yuo-Ling; Davey, David D.; Eagen, Keith A.; Griedel, Brian D.; Karanjawala, Rushad; Phillips, Gary B.; Sacchi, Karna L.; Shaw, Kenneth J.; Wu, Shung C.; Lentz, Dao; Liang, Amy M.; Trinh, Lan; Morrissey, Michael M.; Kochanny, Monica J.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 3 p. 507 - 511
反应条件
1: NEt3 / CH2Cl2 / 20 °C
2: SnCl2*2H2O / ethyl acetate / Heating
View Scheme
参考文献
Chou, Yuo-Ling; Davey, David D.; Eagen, Keith A.; Griedel, Brian D.; Karanjawala, Rushad; Phillips, Gary B.; Sacchi, Karna L.; Shaw, Kenneth J.; Wu, Shung C.; Lentz, Dao; Liang, Amy M.; Trinh, Lan; Morrissey, Michael M.; Kochanny, Monica J.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 3 p. 507 - 511
反应条件
1: diethyl ether
2: aqueous sulfuric acid
View Scheme
参考文献
Szychowski, Janek; Mahdavi, Alborz; Hodas, Jennifer J. L.; Bagert, John D.; Ngo, John T.; Landgraf, Peter; Dieterich, Daniela C.; Schuman, Erin M.; Tirrell, David A.
Journal of the American Chemical Society, 2010 , vol. 132, # 51 p. 18351 - 18360
