3-硝基-4-氯苯甲酰氯合成路线 （共 35 条）
参考文献
Montagne
Recueil des Travaux Chimiques des Pays-Bas, 1900 , vol. 19, p. 55
反应条件
1: tetrachloromethane; aqueous ammonia 2: phosphorus oxychloride / 170 °C 3: aqueous nitric acid View Scheme
参考文献
Um, Ik-Hwan; Kim, Eun-Hee; Kang, Ji-Sun
Organic and Biomolecular Chemistry, 2011 , vol. 9, # 23 p. 8062 - 8067
反应条件
1: AlCl3 / 70 - 85 °C 2: sodium acetate; alcoholic ammonia / 124 - 128 °C / im Einschlussrohr View Scheme
参考文献
Maron; Fox
Chemische Berichte, 1914 , vol. 47, p. 2782
反应条件
carbon disulfide; aluminium trichloride
参考文献
JANSSEN PHARMACEUTICA N.V.
Patent: WO2005/54201 A1, 2005 ;
Location in patent: Page/Page column 49 ;
反应条件
in DMF (N,N-dimethyl-formamide) T=20°C; 1 h;
参考文献
BAYER HEALTHCARE AG
Patent: WO2005/28451 A1, 2005 ;
Location in patent: Page/Page column 36 ;
反应条件
n-butyllithium in tert-butyl alcohol
参考文献
G. D. Searle and Co.
Patent: US5304644 A1, 1994 ;
US 5304644 A
参考文献
Kim, Mi Kyoung; Yoon, Hyunjun; Barnard, Dale Lynn; Chong, Youhoon
Chemical and Pharmaceutical Bulletin, 2013 , vol. 61, # 4 p. 486 - 488
反应条件
aluminium trichloride in dichloromethane 4 h;
参考文献
Kamal, Marwan R.; El-Abadelah, Mustafa M.; Mohammad, Amer A.; Meier, Herbert
Heterocycles, 1999 , vol. 50, # 2 p. 819 - 832
反应条件
AlCl3, aluminium chloride in dichloromethane T=0 - 45°C; Friedel Crafts acylation; 5 h;
参考文献
Tzanova, Tzvetomira; Gerova, Mariana; Petrov, Ognyan; Karaivanova, Margarita; Bagrel, Denyse
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 6 p. 2724 - 2730
反应条件
tetrachloromethane; ammonium hydroxide
参考文献
GLAXOSMITHKLINE LLC; HALLMAN, Jason; LAUDEMAN, Christopher; LIU, Ronggang; MILLER, Aaron; MOORE, Michael, Lee; DOCK, Steven; MUSSO, David; PARRISH, Cynthia
Patent: WO2011/56635 A1, 2011 ;
Location in patent: Page/Page column 145-146 ;
WO 2011/056635 A1
