反应条件
1: 1.) Et3N, methanesulfonyl chloride, 2.) NaH / 1.) CH2Cl2, 0 deg C, 1.5 h, 2.) THF, 15 h
2: 98 percent / H2 / 10percent Pd/C / ethanol / 2 h / 2585.7 Torr
3: 84 percent / BH3/THF / tetrahydrofuran / 0.5 h / Heating
4: 99 percent / 1N aq. HCl / tetrahydrofuran / 3 h / Ambient temperature
5: 90 percent / 1.) DMSO, trifluoroacetic anhydride, 2.) Et3N / 1.) CH2Cl2, -78 deg C, 1 h, 2.) 0 deg C, 0.5 h
6: 84 percent / p-toluenesulfonic acidmonohydrate / dioxane / 22.5 h / Heating
7: 97 percent / NaBH4 / methanol / 1.33 h / Ambient temperature
View Scheme
参考文献
Burkholder; Fuchs
Journal of the American Chemical Society, 1990 , vol. 112, # 26 p. 9601 - 9613
