N-苄氧羰基-L-谷氨酸γ-叔丁酯合成路线 （共 13 条）
反应条件
1: 100 percent / cesium carbonate / dimethylformamide / Ambient temperature
2: 85 percent / H2, AcOH / 5percent Pd/C / methanol / 2280 - 3040 Torr
3: 1.) diethyl phosphorocyanidate, Et3N, 2.) Et3N / 1.) DMF, 80 deg C, 2 min, 2.) DMF, 80 deg C, 2 h
4: 92 percent / Ba(OH)2*8H2O / ethanol; H2O / Ambient temperature
View Scheme
参考文献
Rosowsky, Andre; Forsch, Ronald; Uren, Jack; Wick, Michael
Journal of Medicinal Chemistry, 1981 , vol. 24, # 12 p. 1450 - 1455
反应条件
dicyclohexyl-carbodiimide in dichloromethane
T=20°C; Esterification; 4.3 h; cooling;
参考文献
Jadhav, Sandip V.; Misra, Rajkumar; Singh, Sumeet K.; Gopi, Hosahudya N.
Chemistry - A European Journal, 2013 , vol. 19, # 48 p. 16256 - 16262
反应条件
1: HOBt; EDC
2: TFA / CH2Cl2
View Scheme
参考文献
Smyth; Rose; Mehrotra; Heath; Ruhter; Schotten; Seroogy; Volkots; Pandey; Scarborough
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 10 p. 1289 - 1292
