R(+)-alpha-甲基苄胺合成路线 （共 285 条）
反应条件
in butan-1-ol 15 h; Heating;
参考文献
Barbier, Denis; Marazano, Christian; Das, Bhupesh C.; Potier, Pierre
Journal of Organic Chemistry, 1996 , vol. 61, # 26 p. 9596 - 9598
1182-65-6[10,13-二甲基-17-(6-甲基庚烷-2-基)-2,3,4,7,8,9,11,12,14,15,16,17-十二氢-1H-环戊并[a]菲-3-基] 4-甲基苯磺酸酯
→
反应条件
T=185 - 200°C; 24 h; Yield given. Yields of byproduct given;
参考文献
Anand; Boyce
Archiv der Pharmazie, 1995 , vol. 328, # 6 p. 501 - 504
反应条件
Chromobacterium violaceum ATA-114 1100708MW; ωTA ATA-117 102907WW; pyridoxal 5'-phosphate; pentan-3-one T=30°C; pH=7; 24 h; aq. phosphate bufferEnzymatic reaction;
参考文献
Engstroem, Karin; Johnston, Eric V.; Verho, Oscar; Gustafson, Karl P. J.; Shakeri, Mozaffar; Tai, Cheuk-Wai; Baeckvall, Jan-E.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 52 p. 14006 - 14010
Angew. Chem., 2013 , vol. 52-125, # 52 p. 14256 - 14260
反应条件
BM-ωTA; ωTA ATA-117 102907WW; pyridoxal 5'-phosphate; pentan-3-one T=30°C; pH=7; 24 h; aq. phosphate bufferEnzymatic reaction;
参考文献
Koszelewski, Dominik; Grischek, Barbara; Glueck, Silvia M.; Kroutil, Wolfgang; Faber, Kurt
Chemistry - A European Journal, 2011 , vol. 17, # 1 p. 378 - 383
反应条件
ωTA ATA-117 102907WW; Vibrio fluvialis Vf-ωTA 2100208MW; pyridoxal 5'-phosphate T=30°C; pH=7; 24 h; aq. phosphate buffer;
参考文献
Koszelewski, Dominik; Grischek, Barbara; Glueck, Silvia M.; Kroutil, Wolfgang; Faber, Kurt
Chemistry - A European Journal, 2011 , vol. 17, # 1 p. 378 - 383
反应条件
2,2'-azo-bisisobutyronitrile; thiophenol in benzene 6 h; Heating; Product distribution;
参考文献
Escoubet, Stephanie; Gastaldi, Stephane; Vanthuyne, Nicolas; Gil, Gerard; Siri, Didier; Bertrand, Michele P.
European Journal of Organic Chemistry, 2006 , # 14 p. 3242 - 3250
反应条件
ωTA ATA-117 102907WW; Vibrio fluvialis Vf-ωTA 2100208MW; pyridoxal 5'-phosphate; pentan-3-one T=30°C; pH=7; 24 h; aq. phosphate bufferEnzymatic reaction;
参考文献
Koszelewski, Dominik; Grischek, Barbara; Glueck, Silvia M.; Kroutil, Wolfgang; Faber, Kurt
Chemistry - A European Journal, 2011 , vol. 17, # 1 p. 378 - 383
反应条件
sulfuric acid; sodium nitrite
参考文献
Holmberg
Chemische Berichte, 1912 , vol. 45, p. 999
反应条件
1: With hydrogenchloride in 1,4-dioxane T=40 - 74°C; 20 h; 2: With sulfuric acid in 1,4-dioxane T=100°C; 7 h;
参考文献
Maerki, H. P.; Binggeli, A.; Bittner, B.; Bohner-Lang, V.; Breu, V.; Bur, D.; Coassolo, Ph.; Clozel, J. P.; D'Arcy, A.; Doebeli, H.; Fischli, W.; et al.
Farmaco, 2001 , vol. 56, # 1-2 p. 21 - 28
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FANDRICK, Keith R.; GAO, Ju; LI, Wenjie; LU, Bruce; ZHANG, Yongda
Patent: WO2010/10150 A1, 2010 ;
Location in patent: Page/Page column 45-46 ;
WO 2010/010150 A1
