R(+)-alpha-甲基苄胺合成路线 （共 285 条）
反应条件
sodium hydride in diethyl ether T=0 - 20°C; Condensation;
参考文献
Pache, Sandrine; Botuha, Candice; Franz, Roberto; Kuendig, E. Peter; Einhorn, Jacques
Helvetica Chimica Acta, 2000 , vol. 83, # 9 p. 2436 - 2451
反应条件
triethylamine; trichloroacetonitrile; triphenylphosphine in acetonitrile T=20°C; 2 h; Inert atmosphere;
参考文献
Kim, Joong-Gon; Jang, Doo Ok
Tetrahedron Letters, 2010 , vol. 51, # 4 p. 683 - 685
反应条件
in tetrahydrofuran 4 h; Ambient temperature;
参考文献
Katritzky, Alan R.; Yang, Baozhen; Semenzin, Delphine
Journal of Organic Chemistry, 1997 , vol. 62, # 3 p. 726 - 728
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FANDRICK, Keith R.; GAO, Ju; LI, Wenjie; LU, Bruce; ZHANG, Yongda
Patent: WO2010/10150 A1, 2010 ;
Location in patent: Page/Page column 45-46 ;
WO 2010/010150 A1
反应条件
sodium hydride in diethyl ether T=0 - 20°C; Condensation;
参考文献
Pache, Sandrine; Botuha, Candice; Franz, Roberto; Kuendig, E. Peter; Einhorn, Jacques
Helvetica Chimica Acta, 2000 , vol. 83, # 9 p. 2436 - 2451
反应条件
triethylamine; trichloroacetonitrile; triphenylphosphine in acetonitrile T=20°C; 2 h; Inert atmosphere;
参考文献
Kim, Joong-Gon; Jang, Doo Ok
Tetrahedron Letters, 2010 , vol. 51, # 4 p. 683 - 685
反应条件
in tetrahydrofuran 4 h; Ambient temperature;
参考文献
Katritzky, Alan R.; Yang, Baozhen; Semenzin, Delphine
Journal of Organic Chemistry, 1997 , vol. 62, # 3 p. 726 - 728
反应条件
1: diluted KOH-solution / durch Einw. von Chloressigsaeure auf das so entstandene Kaliumsalz der l-α-Phenaethyl-dithiocarbamidsaeure 2: diluted acetic acid View Scheme
参考文献
Kallenberg
Chemische Berichte, 1919 , vol. 52, p. 2061
反应条件
in water T=15 - 17°C; 0.8 h;
参考文献
Kim, Jeum-Jong; Kweon, Deok-Heon; Cho, Su-Dong; Kim, Ho-Kyun; Jung, Eun-Young; Lee, Sang-Gyeong; Falck; Yoon, Yong-Jin
Tetrahedron, 2005 , vol. 61, # 24 p. 5889 - 5894
反应条件
in 1,3-dimethyl-imidazolidin-2-one T=120°C; 14 h;
参考文献
ASTRAZENECA AB
Patent: US2011/92526 A1, 2011 ;
Location in patent: Page/Page column 24 ;
