R(+)-alpha-甲基苄胺合成路线 （共 285 条）
反应条件
1: Li2O, molecular sieves / tetrahydrofuran 2: NaBH4, HCl / tetrahydrofuran; ethanol View Scheme
参考文献
Kowalczyk, Bruce A.; Rohloff, John C.; Dvorak, Charles A.; Gardner, John O.
Synthetic Communications, 1996 , vol. 26, # 10 p. 2009 - 2015
反应条件
1: 100 percent / toluene / Heating 2: TFA; BF3*Et2O / dimethylformamide / -20 °C View Scheme
参考文献
Bailey, Patrick D.; Wilson, Robert D.; Brown, George R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1991 , # 5 p. 1337 - 1340
反应条件
1: Li2O, molecular sieves / tetrahydrofuran 2: NaBH4, HCl / tetrahydrofuran; ethanol View Scheme
参考文献
Kowalczyk, Bruce A.; Rohloff, John C.; Dvorak, Charles A.; Gardner, John O.
Synthetic Communications, 1996 , vol. 26, # 10 p. 2009 - 2015
反应条件
2: LiAlH4 View Scheme
参考文献
Tetrahedron Letters, , vol. 36, # 46 p. 8431 - 8434
反应条件
in dichloromethane T=20°C; 3 h;
参考文献
Lebrun, Stephane; Couture, Axel; Deniau, Eric; Grandclaudon, Pierre
Organic and biomolecular chemistry, 2003 , vol. 1, # 10 p. 1701 - 1706
反应条件
sulfuric acid in N,N-dimethyl-formamide Reflux;
参考文献
E Sana, Auj; Khan, Sher W.; Ambreen, Nida; Arfan, Muhammad; Zaidi, Javid H.; Khan, Khalid M.; Perveen, Shahnaz; Miana, Ghulam A.
Letters in Organic Chemistry, 2012 , vol. 9, # 9 p. 632 - 638
反应条件
triethylamine in acetone
参考文献
Rao, P. Srirama; Boehme, Stefan; Rao, Savita P.; Reddy, Goukanapalli Chandrasekara
Patent: US2006/69124 A1, 2006 ;
Location in patent: Page/Page column 10; 11 ;
US 20060069124 A1
反应条件
1: (3R,5S)-7-[2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]-3,5-dihydroxy-6(E)-heptanoic acid tert-butyl ester With hydrogenchloride in water; acetonitrile T=20°C; 3 h; 2: (R)-1-phenyl-ethyl-amine in dichloromethane T=20°C; 36 h;
参考文献
HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; MURALIDHARA REDDY, Dasari; MALLA REDDY, Samala; VAMSI KRISHNA, Bandi
Patent: WO2012/63254 A1, 2012 ;
Location in patent: Page/Page column 11 ;
反应条件
acetic acid in isopropyl alcohol T=40°C;
参考文献
DR. REDDY'S LABORATORIES LIMITED; DR. REDDY'S LABORATORIES, INC.
Patent: WO2009/85990 A2, 2009 ;
Location in patent: Page/Page column 29 ;
反应条件
1: With sodium azide; 2,4,6-triphenylpyrylium-tetrafluoroborate; triethylamine in tetrahydrofuran T=20°C; 0.333333 h; 2: With acetic acid in tetrahydrofuran T=20°C; 10 h;
参考文献
Said, Sadri A.; Fiksdahl, Anne
Tetrahedron Asymmetry, 2001 , vol. 12, # 13 p. 1947 - 1951
