R(+)-alpha-甲基苄胺合成路线 （共 285 条）
参考文献
Abderhalden; Schmitz
Biochemische Zeitschrift, 1929 , vol. 214, p. 159
反应条件
2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; sodium t-butanolate; tris(dibenzylideneacetone)dipalladium(0) chloroform complex in toluene
T=95°C; 45 h;
参考文献
Winn, Caroline L.; Guillen, Frederic; Pytkowicz, Julien; Roland, Sylvain; Mangeney, Pierre; Alexakis, Alexandre
Journal of Organometallic Chemistry, 2005 , vol. 690, # 24-25 p. 5672 - 5695
反应条件
1: MgSO4 / methanol
2: NaBH4 / methanol / 20 °C
3: NaNH2 / toluene / Heating
View Scheme
参考文献
Kelleher, Fintan; Kelly, Sinead
Tetrahedron Letters, 2006 , vol. 47, # 30 p. 5247 - 5250
反应条件
1: MgSO4 / methanol
2: NaBH4 / methanol / 20 °C
3: NaNH2 / toluene / Heating
View Scheme
参考文献
Kelleher, Fintan; Kelly, Sinead
Tetrahedron Letters, 2006 , vol. 47, # 30 p. 5247 - 5250
反应条件
1: n-butyllithium / diethyl ether; hexane / 0.25 h / -35 °C / |Inert atmosphere; |Schlenk technique
2: n-butyllithium / hexane / |Inert atmosphere; |Schlenk technique
View Scheme
参考文献
Ye, Fei; Zheng, Zhan-Jiang; Deng, Wen-Hui; Zheng, Long-Sheng; Deng, Yuan; Xia, Chun-Gu; Xu, Li-Wen
Chemistry - An Asian Journal, 2013 , vol. 8, # 9 p. 2242 - 2253
反应条件
1: (R)-1-phenyl-ethyl-amine With trimethylaluminum in hexane; dichloromethane
T=0°C; 1 h;
2: cyclohexane-1,2-epoxide in dichloromethane
T=0 - 20°C; 21 h;
参考文献
Nishida, Atsushi; Shirato, Fumie; Nakagawa, Masako
Tetrahedron Asymmetry, 2000 , vol. 11, # 18 p. 3789 - 3805
反应条件
1: in methanol
T=20°C; 18 h;
2: With toluene-4-sulfonic acid in toluene
16 h; Reflux;
参考文献
MITSUBISHI TANABE PHARMA CORPORATION; SANOFI-AVENTIS; NAKAYAMA, Kazuki; SAKAI, Daiki; WATANABE, Kazutoshi; KOHARA, Toshiyuki; ARITOMO, Keiichi
Patent: WO2011/19090 A1, 2011 ;
Location in patent: Page/Page column 44-45 ;
WO 2011/019090 A1
反应条件
1: 97 percent / 4 h / 160 °C
2: acetyl chloride / 16 h / Heating
View Scheme
参考文献
Nielsen, Lone; Brehm, Lotte; Krogsgaard-Larsen, Povl
Journal of Medicinal Chemistry, 1990 , vol. 33, # 1 p. 71 - 77
参考文献
Davies, Christopher D.; Marsden, Stephen P.; Stokes, Elaine S.E.
Tetrahedron Letters, 2000 , vol. 41, # 21 p. 4229 - 4233
反应条件
1: With 2,4,6-triphenylpyrylium-tetrafluoroborate; triethylamine in tetrahydrofuran
T=20°C; 0.333333 h;
2: With acetic acid in tetrahydrofuran
T=20°C; 10 h;
参考文献
Said, Sadri A.; Fiksdahl, Anne
Tetrahedron Asymmetry, 2001 , vol. 12, # 13 p. 1947 - 1951
