(R)-1-(1-萘基)乙胺合成路线 （共 75 条）
反应条件
heptakis-(6-O-TIPS)-β-CD; triethylamine in cyclohexane T=10°C; 6 h; Resolution of racemate; Reagent/catalystSolventTime; enantioselective reaction;
参考文献
Asahara, Haruyasu; Kida, Toshiyuki; Iwamoto, Takuya; Hinoue, Tomoaki; Akashi, Mitsuru
Tetrahedron, 2014 , vol. 70, # 2 p. 197 - 203
反应条件
heptakis-(6-O-TIPS)-β-CD; triethylamine in cyclohexane T=10°C; 6 h; Resolution of racemate; enantioselective reaction;
参考文献
Asahara, Haruyasu; Kida, Toshiyuki; Iwamoto, Takuya; Hinoue, Tomoaki; Akashi, Mitsuru
Tetrahedron, 2014 , vol. 70, # 2 p. 197 - 203
反应条件
heptakis-(6-O-TIPS)-β-CD; triethylamine in cyclohexane T=10°C; 6 h; Resolution of racemate; enantioselective reaction;
参考文献
Asahara, Haruyasu; Kida, Toshiyuki; Iwamoto, Takuya; Hinoue, Tomoaki; Akashi, Mitsuru
Tetrahedron, 2014 , vol. 70, # 2 p. 197 - 203
反应条件
1: With [((R)-tol-binap)RuCl2(DMF)x]; ammonia; ammonium formate in methanol T=85°C; Leuckart-Wallach reaction; 30 h; 2: With hydrogenchloride in ethanol 1 h; Heating; Title compound not separated from byproducts;
参考文献
Kadyrov, Renat; Riermeier, Thomas H.
Angewandte Chemie - International Edition, 2003 , vol. 42, # 44 p. 5472 - 5474
反应条件
hydrogen; Pd-BaSO4 in toluene T=70°C; P=75.0075 Torr; 24 h;
参考文献
Parvulescu, Andrei N.; Jacobs, Pierre A.; De Vos, Dirk E.
Chemistry - A European Journal, 2007 , vol. 13, # 7 p. 2034 - 2043
反应条件
borane-THF; C19H23BNO3(1-)*H(1+) in tetrahydrofuran; 1,4-dioxane T=0°C; Inert atmosphere; enantioselective reaction;
参考文献
Ou, Wenhua; Espinosa, Sandraliz; Melendez, Hector J.; Farre, Silvia M.; Alvarez, Jaime L.; Torres, Valerie; Martinez, Ileanne; Santiago, Kiara M.; Ortiz-Marciales, Margarita
Journal of Organic Chemistry, 2013 , vol. 78, # 11 p. 5314 - 5327
反应条件
Alkaline protease in 3-methyl pentan-3-ol T=20°C; 1.5 h; Enzymatic reaction; optical yield given as percent ee;
参考文献
Nechab, Malek; El Blidi, Lahssen; Vanthuyne, Nicolas; Gastaldi, Stephane; Bertrand, Michele P.; Gil, Gerard
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 21 p. 3917 - 3920
反应条件
sodium hydroxide; water 0.5 h;
参考文献
DR. REDDY'S LABORATORIES, LTD.; DR. REDDY'S LABORATORIES, INC.
Patent: WO2008/58235 A2, 2008 ;
Location in patent: Page/Page column 24-25 ;
反应条件
NH4Br; ethylenediamine T=80°C; 10 h; Microwave irradiationInert atmosphereneat (no solvent);
参考文献
Shimizu, Yuhei; Morimoto, Hiroyuki; Zhang, Ming; Ohshima, Takashi
Angewandte Chemie - International Edition, 2012 , vol. 51, # 34 p. 8564 - 8567
反应条件
1: 74.9 percent / H2, conc. ammonia / Raney nickel / aq. ethanol / 24 h / 3040 Torr / Ambient temperature View Scheme
参考文献
Mathad, Vijayavitthal T.; Shinde, Gorakshanath B.; Ippar, Sharad S.; Niphade, Navnath C.; Panchangam, Raghavendra K.; Vankawala, Pravinchandra J.
Synthetic Communications, 2011 , vol. 41, # 3 p. 341 - 346
