(R)-1-(1-萘基)乙胺合成路线 （共 75 条）
反应条件
coated protease in 3-methyl pentan-3-ol T=21°C; 168 h; Resolution of racemateEnzymatic reaction; enantioselective reaction;
参考文献
Queyroy, Severine; Vanthuyne, Nicolas; Gastaldi, Stephane; Bertrand, Michele P.; Gil, Gerard
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 9 p. 1759 - 1764
反应条件
2,6-dimethylpyridine; chiral 1-azaspiro[5.5]undecane N-oxyl radical; sodium perchlorate in water; acetonitrile Oxidation; 5 h; Electrolysis;
参考文献
Truppo, Matthew D.; Turner, Nicholas J.; Rozzell, J. David
Chemical Communications, 2009 , # 16 p. 2127 - 2129
反应条件
Candida antarctica lipase in di-isopropyl ether T=30°C; 120 h;
参考文献
Yang, Bo; Zhang, Yanjun; Zhang, Shusheng; Izumi
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 6 p. 1312 - 1316
反应条件
Candida antarctica lipase in di-isopropyl ether T=30°C; 120 h;
参考文献
Yang, Bo; Zhang, Yanjun; Zhang, Shusheng; Izumi
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 6 p. 1312 - 1316
反应条件
potassium hydroxide in dimethyl sulfoxide T=150 - 160°C; 20 h;
参考文献
Mathad, Vijayavitthal T.; Shinde, Gorakshanath B.; Ippar, Sharad S.; Niphade, Navnath C.; Panchangam, Raghavendra K.; Vankawala, Pravinchandra J.
Synthetic Communications, 2011 , vol. 41, # 3 p. 341 - 346
反应条件
1: With hydrogenchloride in methanol T=20°C; 2: With ammonia; ammonium chloride in water
参考文献
Pablo, Oscar; Guijarro, David; Kovacs, Gabor; Lledos, Agusti; Ujaque, Gregori; Yus, Miguel
Chemistry - A European Journal, 2012 , vol. 18, # 7 p. 1969 - 1983
反应条件
(2S)-(-)-2-amino-3-methyl-1,1-diphenylbutan-1-ol-borane in tetrahydrofuran T=30°C; 24 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Itsuno, Shinichi; Nakano, Michio; Miyazaki, Koji; Masuda, Hirofumi; Ito, Koichi; et al.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985 , p. 2039 - 2044
反应条件
1: 75 percent / MgSO4 / CHCl3 / Heating 2: 46 percent / tetrahydrofuran / 2 h / -78 °C 3: 61 percent / lead tetraacetate / methanol; CH2Cl2 / 0.07 h / 0 °C View Scheme
参考文献
Pridgen, Lendon N.; Mokhallalati, Mohamed K.; Wu, Ming-Jung
Journal of Organic Chemistry, 1992 , vol. 57, # 4 p. 1237 - 1241
反应条件
1: 46 percent / tetrahydrofuran / 2 h / -78 °C 2: 61 percent / lead tetraacetate / methanol; CH2Cl2 / 0.07 h / 0 °C View Scheme
参考文献
Pridgen, Lendon N.; Mokhallalati, Mohamed K.; Wu, Ming-Jung
Journal of Organic Chemistry, 1992 , vol. 57, # 4 p. 1237 - 1241
反应条件
1: hydroxylamine hydrochloride; sodium hydroxide / methanol; water / 20 - 35 °C / pH 6 - 6.5 2: ammonia; hydrogen / methanol; water / 58 - 62 °C / 2574.5 - 2942.29 Torr 3: ethanol / 0.75 h / 60 - 65 °C / Resolution of racemate 4: ammonia / water; toluene 5: potassium hydroxide / dimethyl sulfoxide / 20 h / 150 - 160 °C View Scheme
参考文献
Ou, Wenhua; Espinosa, Sandraliz; Melendez, Hector J.; Farre, Silvia M.; Alvarez, Jaime L.; Torres, Valerie; Martinez, Ileanne; Santiago, Kiara M.; Ortiz-Marciales, Margarita
Journal of Organic Chemistry, 2013 , vol. 78, # 11 p. 5314 - 5327
