(R)-1-(1-萘基)乙胺合成路线 （共 75 条）
反应条件
sodium hydroxide; toluene-4-sulfonic acid 1) aq. EtOH, 30 h, 110 deg C, 4 kbar; 2) benzene, 3 h reflux; Yield given. Multistep reaction;
参考文献
Pirkle, William H.; Adams, Paul E.
Journal of Organic Chemistry, 1980 , vol. 45, # 21 p. 4111 - 4117
反应条件
sodium hydroxide; toluene-4-sulfonic acid 1) aq. EtOH, 20 h reflux, 2) benzene, 3 h reflux; Yield given. Multistep reaction;
参考文献
Pirkle, William H.; Adams, Paul E.
Journal of Organic Chemistry, 1980 , vol. 45, # 21 p. 4111 - 4117
反应条件
N,N'-dimethyl-N,N'-propyleneurea T=-20°C; 24 h; Title compound not separated from byproducts;
参考文献
Sabot, Cyrille; Subhash, Pithani V.; Valleix, Alain; Arseniyadis, Stellios; Mioskowski, Charles
Synlett, 2008 , # 2 p. 268 - 272
反应条件
Yield given. Multistep reaction;
参考文献
Gawley, Robert E.; Rein, Kathleen; Chemburkar, Sanjay
Journal of Organic Chemistry, 1989 , vol. 54, # 13 p. 3002 - 3004
反应条件
Yield given. Yields of byproduct given;
参考文献
Wang, Yi-Fong; Yakovlevsky, Kirill; Zhang, Bailing; Margolin, Alexey L.
Journal of Organic Chemistry, 1997 , vol. 62, # 11 p. 3488 - 3495
反应条件
1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine in dichloromethane T=20°C; 15 h; Inert atmosphere;
参考文献
Journal of Organic Chemistry, , vol. 76, # 7 p. 2187 - 2194
反应条件
potassium carbonate in acetonitrile 22 h; Heating / reflux;
参考文献
US2007/259964 A1, ;
Page/Page column 3-5 ;
反应条件
potassium carbonate in dichloromethane T=25 - 27°C; 0.5 - 3 h; Product distribution / selectivity;
参考文献
WO2008/58235 A2, ;
Page/Page column 25-28 ;
反应条件
1H-1,2,4-triazol; 1,8-diazabicyclo[5.4.0]undec-7-ene in chloroform-d1 24 h; Reflux;
参考文献
Journal of Organic Chemistry, , vol. 76, # 7 p. 2187 - 2194
反应条件
in ethyl acetate T=0 - 30°C; 3 h; Product distribution / selectivity;
参考文献
EP1990333 A1, ;
Page/Page column 7-8; 9; 10; 11 ;
