(R)-1-(1-萘基)乙胺合成路线 （共 75 条）
反应条件
1: ; hydrogen; ammonia / 12 h / 200 °C / 46504.7 - 50255 Torr / |Autoclave 2: immobilized lipase B from Candida antarctica (Novozyme 435®) / diethyl ether View Scheme
参考文献
SCHREMS, Marcus Georg
Patent: US2013/345475 A1, 2013 ;
反应条件
1: potassium carbonate, tetra-n-butylammonium iodide / CH2Cl2; H2O / 5 h 2: lithium aluminum hydride / tetrahydrofuran / Heating View Scheme
参考文献
Krane Thvedt, Thor H.; Kaasa, Kristin; Sundby, Eirik; Charnock, Colin; Hoff, Bard Helge
European Journal of Medicinal Chemistry, 2013 , vol. 68, p. 482 - 496
反应条件
dicyclohexyl-carbodiimide in diethyl ether T=-10 - 20°C; 15 h;
参考文献
Tsogoeva, Svetlana B.; Wei, Shengwei
Chemical Communications, 2006 , # 13 p. 1451 - 1453
反应条件
sodium hydrogencarbonate in dichloromethane; water T=20°C; Condensation;
参考文献
Jeon, Dong Ju; Kim, Jung Soo; Lee, Jung No; Kim, Hyoung Rae; Ryu, Eung K.
Chemistry Letters, 2000 , # 1 p. 40 - 41
反应条件
1: CH2Cl2 / 1 h / 20 °C 2: 2-chloro-1,3-dimethylimidazolinium chloride / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Isobe; Fukuda; Tokunaga; Seki; Yamaguchi; Ishikawa
Journal of Organic Chemistry, 2000 , vol. 65, # 23 p. 7774 - 7778
反应条件
1: in methanol T=5 - 10°C; 2: With hydrogen; palladium(II) oxide hydrate in methanol T=25 - 30°C; P=2206.72 Torr; 3 h;
参考文献
WO2010/67204 A1, ;
Page/Page column 44-45 ;
反应条件
1: in tetrahydrofuran 0.25 h; 2: With sodium tris(acetoxy)borohydride; acetic acid in tetrahydrofuran 2 h; 3: With sodium carbonate in dichloromethane; water Product distribution / selectivity;
参考文献
WO2008/68625 A2, ;
Page/Page column 18 ;
反应条件
potassium carbonate T=105°C; 6 h; Product distribution / selectivity;
参考文献
WO2008/63645 A1, ;
Page/Page column 9 ;
反应条件
hydrogen; bis(1,5-cyclooctadiene)-rhodium(I) tetrafluoroborate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in methanol; toluene T=125°C; 8 h; Product distribution / selectivity;
参考文献
WO2009/2427 A2, ;
Page/Page column 42-43 ;
反应条件
1: 3-lt;3-(trifluoromethyl)phenylgt;propan-1-ol With 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; [bis(acetoxy)iodo]benzene in dichloromethane T=20°C; 2 h; 2: (R)-(+)-1-(1-naphthyl)-ethylamine With sodium tris(acetoxy)borohydride in dichloromethane optical yield given as percent ee;
参考文献
European Journal of Organic Chemistry, , # 15 p. 2990 - 3000
