1-(4-羟苯基)哌嗪二氰溴化物合成路线 （共 10 条）
反应条件
hydrogen bromide T=140°C; 4 h;
参考文献
Chapman; Bauer; Waller; Zaneveld
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 7 p. 2063 - 2068
反应条件
hydrogen bromide Heatingovernight;
参考文献
Stefancich; Artico; Ortar; Silvestri; Simonetti; Apuzzo
Archiv der Pharmazie, 1992 , vol. 325, # 11 p. 687 - 694
反应条件
water; hydrogen bromide
参考文献
Prelog; Blazek
Collection of Czechoslovak Chemical Communications, 1934 , vol. 6, p. 211,218
反应条件
1: butan-1-ol 2: water; HBr View Scheme
参考文献
Prelog; Blazek
Collection of Czechoslovak Chemical Communications, 1934 , vol. 6, p. 211,218
反应条件
1: butan-1-ol 2: water; HBr View Scheme
参考文献
Prelog; Blazek
Collection of Czechoslovak Chemical Communications, 1934 , vol. 6, p. 211,218
反应条件
sodium iodide in N,N-dimethyl-formamide
参考文献
Hoechst Aktiengesellschaft
Patent: US4824846 A1, 1989 ;
反应条件
sodium carbonate in water; toluene 18 h; Heating;
参考文献
Chapman; Bauer; Waller; Zaneveld
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 7 p. 2063 - 2068
反应条件
anhydrous sodium hydrogen carbonate; acetic anhydride; potassium carbonate in hydrogenchloride; water
参考文献
Janssen Pharmaceutica N.V.
Patent: US4144346 A1, 1979 ;
反应条件
1: 100 percent / sodium acetate / acetic acid / 0.75 h / Heating 2: 92 percent / KHCO3, H2O / methanol / Ambient temperature View Scheme
参考文献
Chapman; Bauer; Waller; Zaneveld
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 7 p. 2063 - 2068
反应条件
1: 97 percent / pyridine / 0.5 h
2: 1N aq. NaOH / 12 h / Heating
View Scheme
参考文献
Chapman; Bauer; Waller; Zaneveld
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 7 p. 2063 - 2068
