1-(4-甲氧苯基)哌嗪盐酸盐合成路线 （共 9 条）
反应条件
sodium carbonate in butan-1-ol
参考文献
Xiao, Zhihui; Yuan, Mu; Zhang, Si; Wu, Jun; Qi, Shuhua; Li, Qingxin
Magnetic Resonance in Chemistry, 2005 , vol. 43, # 10 p. 869 - 872
反应条件
1: 88 percent / 48percent HBr / 4 h / 140 °C 2: 100 percent / Na2CO3 / toluene; H2O / 18 h / Heating View Scheme
参考文献
Chapman; Bauer; Waller; Zaneveld
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 7 p. 2063 - 2068
反应条件
hydrogen bromide T=140°C; 4 h;
参考文献
Chapman; Bauer; Waller; Zaneveld
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 7 p. 2063 - 2068
反应条件
1: H2, NaOAc / 10percent Pd/C / methanol 2: 85 percent / 48percent HBr / Heating View Scheme
参考文献
Heeres, J.; Hendrickx, R.; Cutsem, J.Van
Journal of Medicinal Chemistry, 1983 , vol. 26, # 4 p. 611 - 613
反应条件
1: H2, NaOAc / 10percent Pd/C / methanol 2: 85 percent / 48percent HBr / Heating 3: 1.) NaH / 1.) Me2SO, 1 h, 2.) Me2SO, 80 deg C, 4 h View Scheme
参考文献
Heeres, J.; Hendrickx, R.; Cutsem, J.Van
Journal of Medicinal Chemistry, 1983 , vol. 26, # 4 p. 611 - 613
反应条件
1: 88 percent / 48percent HBr / 4 h / 140 °C 2: pyridine / 12 h / Ambient temperature 3: NH4OH / methanol / Ambient temperature; 12 + 2 h View Scheme
参考文献
Chapman; Bauer; Waller; Zaneveld
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 7 p. 2063 - 2068
反应条件
potassium carbonate in N,N-dimethyl-formamide; isobutyl methylketone
参考文献
Janssen Pharmaceutica, N.V.
Patent: US4267179 A1, 1981 ;
反应条件
1: 88 percent / 48percent HBr / 4 h / 140 °C
2: 97 percent / pyridine / 0.5 h
3: 1N aq. NaOH / 12 h / Heating
View Scheme
参考文献
Chapman; Bauer; Waller; Zaneveld
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 7 p. 2063 - 2068
反应条件
hydrogen; sodium acetate; palladium on activated charcoal in methanol
参考文献
Heeres, J.; Hendrickx, R.; Cutsem, J.Van
Journal of Medicinal Chemistry, 1983 , vol. 26, # 4 p. 611 - 613
