4-(4-氟苯基)-哌啶-4-醇盐酸盐合成路线 （共 7 条）
反应条件
palladium hydroxide on carbon; hydrogen in methanol
参考文献
NOVIRA THERAPEUTICS, INC.; HARTMAN, George D.; FLORES, Osvaldo A.
Patent: WO2013/96744 A1, 2013 ;
Location in patent: Page/Page column 213 ;
反应条件
hydrogenchloride; methanol in ethyl acetate T=10 - 35°C; 2 h;
参考文献
Chen, Gang; Xia, Hongguang; Cai, Yu; Ma, Dawei; Yuan, Junying; Yuan, Chengye
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 1 p. 234 - 239
反应条件
potassium hydroxide in ethanol 2 h; Heating;
参考文献
Protiva; Kopicova; Grimova
Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 2 p. 636 - 643
反应条件
1: 90 percent / diethyl ether 2: 87 percent / KOH / ethanol / 2 h / Heating View Scheme
参考文献
Protiva; Kopicova; Grimova
Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 2 p. 636 - 643
反应条件
1: 90 percent / diethyl ether 2: 87 percent / KOH / ethanol / 2 h / Heating View Scheme
参考文献
Protiva; Kopicova; Grimova
Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 2 p. 636 - 643
反应条件
1.1: n-butyllithium / tetrahydrofuran / 0.25 h / -78 °C / |Inert atmosphere 1.2: 3 h / -78 - 20 °C 2.1: palladium hydroxide on carbon; hydrogen / methanol View Scheme
参考文献
NOVIRA THERAPEUTICS, INC.; HARTMAN, George D.; FLORES, Osvaldo A.
Patent: WO2013/96744 A1, 2013 ;
反应条件
sodium hydroxide; water
参考文献
Janssen et al.
Journal of Medicinal and Pharmaceutical Chemistry, 1959 , vol. 1, p. 281,284
