Fmoc-(±)-反式-2-氨基环己烷-1-羧酸合成路线 （共 11 条）
反应条件
sodium hydrogencarbonate in water; acetone T=0 - 20°C;
参考文献
Schinnerl, Marina; Murray, Justin K.; Langenhan, Joseph M.; Gellman, Samuel H.
European Journal of Organic Chemistry, 2003 , # 4 p. 721 - 726
反应条件
sodium hydroxide in tetrahydrofuran; water
参考文献
Berkessel, Albrecht; Glaubitz, Katja; Lex, Johann
European Journal of Organic Chemistry, 2002 , # 17 p. 2948 - 2952
反应条件
1: HCl / dioxane / 1 h / 20 °C 2: 2.17 g / DIEA / acetonitrile / 0.5 h / 20 °C View Scheme
参考文献
Raguse, Tami L.; Porter, Emilie A.; Weisblum, Bernard; Gellman, Samuel H.
Journal of the American Chemical Society, 2002 , vol. 124, # 43 p. 12774 - 12785
反应条件
1: 97 percent / aq. LiOH; aq. H2O2 / methanol / 36 h / 20 °C 2: HCl / dioxane / 1 h / 20 °C 3: 2.17 g / DIEA / acetonitrile / 0.5 h / 20 °C View Scheme
参考文献
Raguse, Tami L.; Porter, Emilie A.; Weisblum, Bernard; Gellman, Samuel H.
Journal of the American Chemical Society, 2002 , vol. 124, # 43 p. 12774 - 12785
反应条件
1.1: 87 percent / p-TsOH / benzene / 4 h / Heating 2.1: NaBH4; isobutyric acid / toluene / 3 h / 0 °C 2.2: HBr / ethyl acetate; propionic acid / 0 °C 2.3: 49 percent / aq. NaHCO3 3.1: 82 percent / Na / ethanol / 15 h / 80 °C 4.1: 3.44 g / HCl / ethyl acetate; dioxane / 0 - 20 °C 5.1: LiOH*H2O / tetrahydrofuran; ethanol; H2O / 36 h / 0 °C 6.1: HCO2NH4 / Pd/C / methanol / 2 h / Heating 7.1: 2.52 g / NaHCO3 / acetone; H2O / 0 - 20 °C View Scheme
参考文献
Schinnerl, Marina; Murray, Justin K.; Langenhan, Joseph M.; Gellman, Samuel H.
European Journal of Organic Chemistry, 2003 , # 4 p. 721 - 726
反应条件
1.1: NaBH4; isobutyric acid / toluene / 3 h / 0 °C 1.2: HBr / ethyl acetate; propionic acid / 0 °C 1.3: 49 percent / aq. NaHCO3 2.1: 82 percent / Na / ethanol / 15 h / 80 °C 3.1: 3.44 g / HCl / ethyl acetate; dioxane / 0 - 20 °C 4.1: LiOH*H2O / tetrahydrofuran; ethanol; H2O / 36 h / 0 °C 5.1: HCO2NH4 / Pd/C / methanol / 2 h / Heating 6.1: 2.52 g / NaHCO3 / acetone; H2O / 0 - 20 °C View Scheme
参考文献
Schinnerl, Marina; Murray, Justin K.; Langenhan, Joseph M.; Gellman, Samuel H.
European Journal of Organic Chemistry, 2003 , # 4 p. 721 - 726
反应条件
1: 82 percent / Na / ethanol / 15 h / 80 °C 2: 3.44 g / HCl / ethyl acetate; dioxane / 0 - 20 °C 3: LiOH*H2O / tetrahydrofuran; ethanol; H2O / 36 h / 0 °C 4: HCO2NH4 / Pd/C / methanol / 2 h / Heating 5: 2.52 g / NaHCO3 / acetone; H2O / 0 - 20 °C View Scheme
参考文献
Schinnerl, Marina; Murray, Justin K.; Langenhan, Joseph M.; Gellman, Samuel H.
European Journal of Organic Chemistry, 2003 , # 4 p. 721 - 726
反应条件
1: 3.44 g / HCl / ethyl acetate; dioxane / 0 - 20 °C 2: LiOH*H2O / tetrahydrofuran; ethanol; H2O / 36 h / 0 °C 3: HCO2NH4 / Pd/C / methanol / 2 h / Heating 4: 2.52 g / NaHCO3 / acetone; H2O / 0 - 20 °C View Scheme
参考文献
Schinnerl, Marina; Murray, Justin K.; Langenhan, Joseph M.; Gellman, Samuel H.
European Journal of Organic Chemistry, 2003 , # 4 p. 721 - 726
反应条件
1: HCO2NH4 / Pd/C / methanol / 2 h / Heating 2: 2.52 g / NaHCO3 / acetone; H2O / 0 - 20 °C View Scheme
参考文献
Schinnerl, Marina; Murray, Justin K.; Langenhan, Joseph M.; Gellman, Samuel H.
European Journal of Organic Chemistry, 2003 , # 4 p. 721 - 726
反应条件
1.1: acetyl chloride / Heating 1.2: NH3 gas / CH2Cl2 / 20 °C 1.3: 74 percent / phenyliodine(III) trifluoroacetate / acetonitrile; H2O / 20 °C 2.1: 81 percent / sodium hydroxide / tetrahydrofuran; H2O View Scheme
参考文献
Berkessel, Albrecht; Glaubitz, Katja; Lex, Johann
European Journal of Organic Chemistry, 2002 , # 17 p. 2948 - 2952
