1: With N-Boc-o-nitrobenzenesulfonamide-aminomethyl polystyrene res; triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran T=20°C; Mitsunobu reaction; 2: With trifluoroacetic acid in dichloromethane T=20°C; 3: With beta-hydroxyethylmercaptan; 1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile T=20°C;
参考文献
Congreve, Miles S.; Kay, Corinne; Scicinski, Jan J.; Ley, Steven V.; Williams, Geoffrey; Murray, Peter J.; McKeown, Stephen C.; Watson, Stephen P.
Tetrahedron Letters, 2003 , vol. 44, # 21 p. 4153 - 4156
1: N-(2-hydroxyethyl)-phthalimide With sodium hydride in N,N-dimethyl-formamide Solid phase reaction; 2: acetyl-bromide With zinc dibromide in dichloromethane Solid phase reaction;
