2,2-二甲基乙酰乙酸甲酯合成路线 （共 44 条）
反应条件
potassium hydroxide in dimethyl sulfoxide; toluene 0.666667 h; Ambient temperature;
参考文献
Johnstone, Robert A. W.; Tuli, Deepak; Rose, Malcolm E.
Journal of Chemical Research, Miniprint, 1980 , # 9 p. 3593 - 3597
反应条件
1: acetoacetic acid methyl ester With sodium hydride in tetrahydrofuran T=0°C; 0.5 h; 2: methyl iodide in tetrahydrofuran T=0 - 20°C; 1 h; 3: methyl iodide With sodium hydride more than 3 stages;
参考文献
Hadida Ruah, Sara S.; Grootenhuis, Peter D.J.; Van Goor, Frederick; Zhou, Jinglan; Bear, Brian; Miller, Mark T.; McCartney, Jason; Numa, Mehdi Michel Jamel
Patent: US2007/244159 A1, 2007 ;
Location in patent: Page/Page column 129 ;
反应条件
CH3I; N2; NaH in tetrahydrofuran
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
N2; NaH in tetrahydrofuran
参考文献
Monsanto Company
Patent: US5475013 A1, 1995 ;
US 5475013 A
反应条件
hydrogenchloride; acetic anhydride in benzene
参考文献
Shell Oil Company
Patent: US4626543 A1, 1986 ;
反应条件
2,2'-azo-bisisobutyronitrile; tri-n-butyl-tin hydride in benzene 0.5 h; Heating;
参考文献
Beckwith,A.L.; O'Shea,D.M.; Westwood,S.W.
Journal of the American Chemical Society, 1988 , vol. 110, p. 2565
反应条件
1: 45 percent / NaH / dimethylsulfoxide / 3 h / Ambient temperature 2: 9 percent / Bu3SnH, AIBN / benzene / 0.5 h / Heating View Scheme
参考文献
Beckwith,A.L.; O'Shea,D.M.; Westwood,S.W.
Journal of the American Chemical Society, 1988 , vol. 110, p. 2565
反应条件
zinc in 1,4-dioxane; diethyl ether Substitution; 0.166667 h; Heating;
参考文献
Fotin; Shchepin; Vakhrin
Russian Journal of Organic Chemistry, 1999 , vol. 35, # 9 p. 1278 - 1281
反应条件
Ti-β titanium silicate in dichloromethane T=39.84°C; 5 h; regioselective reaction;
参考文献
Sasidharan, Manickam; Bhaumik, Asim
Journal of Molecular Catalysis A: Chemical, 2011 , vol. 346, # 1-2 p. 87 - 93
反应条件
boron trifluoride diethyl etherate; mercury(II) oxide in tetrahydrofuran; methanol Ambient temperature; Yield given;
参考文献
Kende, Andrew S.; Becker, David A.
Synthetic Communications, 1982 , vol. 12, # 11 p. 829 - 832
