2,2-二甲基乙酰乙酸甲酯合成路线 （共 44 条）
反应条件
1: PCl5, DMF / CH2Cl2 2: NaOH / H2O 3: NaNH2 / dimethylsulfoxide View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: 91 percent / NaBH4 / methanol 2: 78 percent / P2O5 / benzene 3: 84 percent / LiOH, H2O / ethanol / Ambient temperature View Scheme
参考文献
Synlett, , # 7 p. 789 - 791
反应条件
1: PCl5, DMF / CH2Cl2 2: NaOH / H2O 3: NaNH2 / dimethylsulfoxide 5: Irradiation View Scheme
参考文献
Schexnayder,M.A.; Engel,P.S.
Journal of the American Chemical Society, 1975 , vol. 97, p. 4825 - 4836
参考文献
Backer; Meyer
Recueil des Travaux Chimiques des Pays-Bas, 1926 , vol. 45, p. 94
Full Text Show Details
Verkade; Dhont
Recueil des Travaux Chimiques des Pays-Bas, 1945 , vol. 64, p. 165,172
反应条件
1: nitric acid 2: sodium ethylate; alcohol View Scheme
参考文献
Perkin
Journal of the Chemical Society, 1903 , vol. 83, p. 1249
反应条件
1: 88 percent / tetrahydrofuran
2: 78 percent / P2O5 / benzene
3: 84 percent / LiOH, H2O / ethanol / Ambient temperature
4: SOCl2
View Scheme
参考文献
Kim, Hyoung Rae; Shin, Seung Il; Park, Hyun Ju; Jeon, Dong Ju; Ryu, Eung K.
Synlett, 1998 , # 7 p. 789 - 791
参考文献
Zhu, Yun-Fei; Guo, Zhiqiang; Gross, Timothy D.; Gao, Yinghong; Connors Jr., Patrick J.; Struthers, R. Scott; Xie, Qiu; Tucci, Fabio C.; Reinhart, Greg J.; Wu, Dongpei; Saunders, John; Chen, Chen
Journal of Medicinal Chemistry, 2003 , vol. 46, # 9 p. 1769 - 1772
反应条件
nitric acid
Bei der Einw. von konz. waessr. Ammoniak auf die entstehende Verbindung;
参考文献
Perkin
Journal of the Chemical Society, 1903 , vol. 83, p. 1249
反应条件
phosphorus pentachloride; N,N-dimethyl-formamide in dichloromethane
T=0°C; Reflux;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED; RUAH, Sara, Hadida, S.; GROOTENHUIS, Peter, D., J.; VAN GOOR, Fredrick; MILLER, Mark, T.; MCCARTNEY, Jason; ZHOU, Jinglan; BEAR, Brian; NUMA, Mehdi, Michel, Djamel
Patent: WO2010/53471 A1, 2010 ;
Location in patent: Page/Page column 58-59 ;
反应条件
phosphorus pentachloride; N,N-dimethyl-formamide in dichloromethane
参考文献
Schexnayder,M.A.; Engel,P.S.
Journal of the American Chemical Society, 1975 , vol. 97, p. 4825 - 4836
