3-溴-5-乙酰基吡啶合成路线

参考文献

F. HOFFMANN-LA ROCHE AG; AEBI, Johannes; AMREIN, Kurt; HORNSPERGER, Benoit; KNUST, Henner; KUHN, Bernd; LIU, Yongfu; MAERKI, Hans P.; MAYWEG, Alexander V.; MOHR, Peter; TAN, Xuefei; ZHOU, Mingwei
Patent: WO2013/37779 A1, 2013 ;
Location in patent: Page/Page column 235; 236 ;

39620-02-55-溴吡啶-3-羰酰氯+

105-53-3丙二酸二乙酯

38940-62-43-溴-5-乙酰基吡啶

参考文献

Dr. Karl Thomae, GmbH
Patent: US5026702 A1, 1991 ;

39620-02-55-溴吡啶-3-羰酰氯+

75-16-1甲基溴化镁

38940-62-43-溴-5-乙酰基吡啶

参考文献

NOVARTIS AG; LEGRAND, Darren, Mark
Patent: WO2009/10530 A1, 2009 ;
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WO 2009/010530 A1

20986-40-75-溴烟酸乙酯

38940-62-43-溴-5-乙酰基吡啶

参考文献

Li, Chun; Girard, Mario; Hamel, Pierre; Laliberte, Sebastien; Friesen, Richard; Girard, Yves; Guay, Daniel
Patent: US2003/96829 A1, 2003 ;

20986-40-75-溴烟酸乙酯+

75-16-1甲基溴化镁

38940-62-43-溴-5-乙酰基吡啶

参考文献

Albaneze-Walker, Jennifer; Ceglia, Scott; Murry, Jerry Anthony; Soheili, Arash
Patent: US2004/102472 A1, 2004 ;
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US 20040102472 A1

20826-04-45-溴烟酸

38940-62-43-溴-5-乙酰基吡啶

参考文献

F. HOFFMANN-LA ROCHE AG; AEBI, Johannes; AMREIN, Kurt; HORNSPERGER, Benoit; KNUST, Henner; KUHN, Bernd; LIU, Yongfu; MAERKI, Hans P.; MAYWEG, Alexander V.; MOHR, Peter; TAN, Xuefei; ZHOU, Mingwei
Patent: WO2013/37779 A1, 2013 ;

59-67-6烟酸

38940-62-43-溴-5-乙酰基吡啶

参考文献

Bachman; Micucci
Journal of the American Chemical Society, 1948 , vol. 70, p. 2381,2383

39620-02-55-溴吡啶-3-羰酰氯

38940-62-43-溴-5-乙酰基吡啶

参考文献

Bachman; Micucci
Journal of the American Chemical Society, 1948 , vol. 70, p. 2381,2383

20986-40-75-溴烟酸乙酯+

141-78-6乙酸乙酯

38940-62-43-溴-5-乙酰基吡啶

参考文献

Bachman; Micucci
Journal of the American Chemical Society, 1948 , vol. 70, p. 2381,2383

38940-62-43-溴-5-乙酰基吡啶+

75-16-1甲基溴化镁

40472-88-63-溴-5-(1-丙烯-2-基)吡啶

参考文献

MERCK SHARP and DOHME CORP.; ALI, Amjad; BENNETT, D. Jonathan; CAI, Jaiqiang; CARSWELL, Emma; COOKE, Andrew; HOYT, Scott, B.; LO, Michael; LONDON, Clare; MACLEAN, John; PARK, Min, K.; RATCLIFFE, Paul; TAYLOR, Jerry Andrew; WHITEHEAD, Brent; XIONG, Yusheng
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